Retinal imaging in Alzheimer's and neurodegenerative diseases.

Aged Aged, 80 and over Alzheimer Disease / diagnostic imaging Biomarkers Brain / diagnostic imaging Humans Middle Aged Neurodegenerative Diseases / diagnostic imaging Retina / diagnostic imaging
Alzheimer's disease biomarkers early detection eye neurodegeneration retina retinal imaging

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
01 2021
Historique:
received: 26 05 2020
revised: 26 07 2020
accepted: 27 07 2020
pubmed: 23 10 2020
medline: 26 10 2021
entrez: 22 10 2020
Statut: ppublish

Résumé

In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying biological changes associated with AD, and for tracking progression of disease severity over time. As different retinal imaging modalities provide different types of structural and/or functional information, the discussion reflected on these modalities and their respective strengths and weaknesses. Discussion further focused on the importance of defining the context of use to help guide the development of retinal biomarkers. Moving from research to context of use, and ultimately to clinical evaluation, this article outlines ongoing retinal imaging research today in Alzheimer's and other brain diseases, including a discussion of future directions for this area of study.

Identifiants

DOI: 10.1002/alz.12179 PMID: 33090722 PMC: PMC8062064
pubmed: 33090722
doi: 10.1002/alz.12179
pmc: PMC8062064
mid: NIHMS1691189
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103-111

Subventions

Organisme : NIA NIH HHS
ID : P01 AG012435
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055865
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056478
Pays : United States

Informations de copyright

© 2020 Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Peter J Snyder (PJ)

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island.

Jessica Alber (J)

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island.

Clemens Alt (C)

Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Lisa J Bain (LJ)

Independent Science Writer, Elverson, Pennsylvania.

Brett E Bouma (BE)

Harvard Medical School, Massachusetts General Hospital and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Massachusetts.

Femke H Bouwman (FH)

Neurologist, Alzheimer Center Amsterdam UMC, Amsterdam, The Netherlands.

Delia Cabrera DeBuc (DC)

Bascom Palmer Eye Institute, University of Miami, Miami, Florida.

Melanie C W Campbell (MCW)

Physics and Astronomy, Optometry and Vision Science and Systems Design Engineering, University of Waterloo, Waterloo, Ontario, Canada.

Maria C Carrillo (MC)

Medical & Scientific Relations, Alzheimer's Association, Chicago, Illinois.

Emily Y Chew (EY)

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

M Francesca Cordeiro (MF)

Imperial College London, UCL Institute of Ophthalmology, ICORG Western Eye Hospital, London, UK.

Michael R Dueñas (MR)

Chief Public Health Officer (Ret.), American Optometric Association, Washington, D.C.

Brian M Fernández (BM)

Clinical Affairs, Heidelberg Engineering, Franklin, Massachusetts.

Maya Koronyo-Hamaoui (M)

Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute and Department of Biomedical Sciences, Division of Applied Cell Biology and Physiology, Cedars-Sinai Medical Center, Los Angeles, California.

Chiara La Morgia (C)

IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
Dipartimento di Scienze Biomediche e Neuromotorie, University of Bologna, Italy.

Roxana O' Carare (RO)

University of Southampton, Southampton, UK.

Srinivas R Sadda (SR)

Doheny Eye Institute, Los Angeles, California.
Department of Ophthalmology, UCLA, Los Angeles, California.

Peter van Wijngaarden (P)

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Ophthalmology, Department of Surgery, University of Melbourne, Parkville, Australia.

Heather M Snyder (HM)

Medical & Scientific Relations, Alzheimer's Association, Chicago, Illinois.
ORCID: 0000-0002-7665-7696

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Retinal imaging in Alzheimer's and...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Retinal imaging in Alzheimer's and...