A molecular understanding of alphavirus entry.
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
1
1
2021
Statut:
epublish
Résumé
Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway, including attachment, internalization, and fusion. Herein, we review recent developments in the molecular understanding of alphavirus entry both in vitro and in vivo and how these advances might enable the design of therapeutics targeting this critical step in the alphavirus life cycle.
Identifiants
pubmed: 33091085
doi: 10.1371/journal.ppat.1008876
pii: PPATHOGENS-D-20-01392
pmc: PMC7580943
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1008876Subventions
Organisme : NIAID NIH HHS
ID : R01 AI123348
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143673
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114816
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142790
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095436
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Déclaration de conflit d'intérêts
M.S.D. is a consultant for Inbios, Vir Biotechnology, NGM Biopharmaceuticals, and on the Scientific Advisory Board of Moderna. The Diamond laboratory has received unrelated funding under sponsored research agreements from Vir Biotechnology, Moderna, and Emergent BioSolutions.
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