Respiratory function, autonomic dysfunction, and systemic inflammation are closely linked in patients with COPD and tidal flow limitation: An exploratory study.
Autonomic dysfunction
C reactive protein
COPD
Dynamic hyperinflation
Systemic inflammation
Tidal expiratory flow limitation
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
24
06
2020
revised:
14
10
2020
accepted:
15
10
2020
pubmed:
23
10
2020
medline:
25
11
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
The study aimed to investigate the interplay among respiratory function, autonomic dysfunction, and systemic inflammation in COPD patients. In 19 COPD patients, functional respiratory parameters, heart rate variability (HRV), and plasma high-sensitivity-C-reactive-protein (hs-CRP) were assessed. Forced oscillation technique (FOT) was used to detect the absence (NFL) or presence (FL) of resting tidal expiratory flow limitation. Subsequently, patients underwent an incremental shuttle walking test (ISWT). Twenty healthy subjects were also shown as controls. FEV Worse airflow obstruction was associated with a higher LH/HF ratio, directly related, to hs-CRP and indices of dynamic hyperinflation. The presence of resting tidal FL with dynamic pulmonary hyperinflation is a strong driver of systemic inflammation and autonomic dysfunction.
Identifiants
pubmed: 33091628
pii: S1569-9048(20)30223-8
doi: 10.1016/j.resp.2020.103565
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103565Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.