Phosphoinositide 3'-Kinase γ Facilitates Polyomavirus Infection.
JC virus
PI3Kγ
PML
SV40
polyomavirus
progressive multifocal leukoencephalopathy
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
20 10 2020
20 10 2020
Historique:
received:
17
09
2020
revised:
12
10
2020
accepted:
13
10
2020
entrez:
23
10
2020
pubmed:
24
10
2020
medline:
27
2
2021
Statut:
epublish
Résumé
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating polyomavirus entry are poorly understood. Through genetic knockdown approaches, we identified phosphoinositide 3'-kinase γ (PI3Kγ) and its regulatory subunit PIK3R5 as cellular proteins that facilitate infection of human SVG-A glial cells by JCPyV. PI3Kα appears less important for polyomavirus infection than PI3Kγ. CRISPR/Cas9-mediated knockout of PIK3R5 or PI3Kγ inhibited infection by authentic JCPyV and by JC pseudovirus. PI3Kγ knockout also inhibited infection by BK and Merkel Cell pseudoviruses, other pathogenic human polyomaviruses, and SV40, an important model polyomavirus. Reintroduction of the wild-type
Identifiants
pubmed: 33092168
pii: v12101190
doi: 10.3390/v12101190
pmc: PMC7589550
pii:
doi:
Substances chimiques
Phosphatidylinositols
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P01 NS065719
Pays : United States
Organisme : NIH HHS
ID : P01 NS065719
Pays : United States
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