Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health.
epidemiology
global health
hepatitis E
infection
outbreak
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
20 Oct 2020
20 Oct 2020
Historique:
received:
22
09
2020
revised:
09
10
2020
accepted:
16
10
2020
entrez:
23
10
2020
pubmed:
24
10
2020
medline:
24
10
2020
Statut:
epublish
Résumé
Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view of the global circulation and epidemiology of this emerging virus. The history of HEV, from the first reported enteric non-A non-B hepatitis outbreaks, to the discovery of the viral agent and the molecular characterization of the different human pathogenic genotypes, is discussed. Furthermore, the current state of research regarding the virology of HEV is critically assessed, and the challenges towards prevention and diagnosis, as well as clinical risks of the disease described. Together, these points aim to underline the significant impact of hepatitis E on global health and the need for further in-depth research to better understand the pathophysiology and its role in the complex disease manifestations of HEV infection.
Identifiants
pubmed: 33092306
pii: pathogens9100856
doi: 10.3390/pathogens9100856
pmc: PMC7589794
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Bundesministerium für Gesundheit
ID : ZMVI1-2518FSB705
Organisme : Bundesministerium für Gesundheit
ID : ZMVI1-2519GHP711
Organisme : Bundesministerium für Wissenschaft und Forschung
ID : BMBF01DP19006A
Organisme : Bundesministerium für Wissenschaft und Forschung
ID : BMBF01DP17047
Organisme : Claussen-Simon-Stiftung
ID : Dissertation Plus
Organisme : FAZIT Stiftung
ID : Promotions Stipendium
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