Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers.
amyloid fibrils
dimer formation
dimer-induced aggregation
disulfide bond
kinetic analysis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
pubmed:
24
10
2020
medline:
8
1
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
Amyloid formation involves the conversion of soluble protein species to an aggregated state. Amyloid fibrils of β-parvalbumin, a protein abundant in fish, act as an allergen but also inhibit the in vitro assembly of the Parkinson protein α-synuclein. However, the intrinsic aggregation mechanism of β-parvalbumin has not yet been elucidated. We performed biophysical experiments in combination with mathematical modeling of aggregation kinetics and discovered that the aggregation of β-parvalbumin is initiated by the formation of dimers stabilized by disulfide bonds and then proceeds via primary nucleation and fibril elongation processes. Dimer formation is accelerated by H
Identifiants
pubmed: 33093204
pii: 2015503117
doi: 10.1073/pnas.2015503117
pmc: PMC7668186
doi:
Substances chimiques
Amyloid
0
Amyloidogenic Proteins
0
Disulfides
0
Parvalbumins
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
27997-28004Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Swiss Med Wkly. 2015 May 29;145:w14128
pubmed: 26023765
R Soc Open Sci. 2017 Jan 4;4(1):160696
pubmed: 28280572
Exp Neurobiol. 2015 Dec;24(4):325-40
pubmed: 26713080
Protein Sci. 2007 Sep;16(9):1914-26
pubmed: 17766386
Angew Chem Int Ed Engl. 2011 Jul 25;50(31):7048-51
pubmed: 21671315
PLoS Biol. 2006 Jan;4(1):e6
pubmed: 16300414
PLoS One. 2012;7(12):e50027
pubmed: 23272053
Biophys J. 2018 Feb 27;114(4):885-892
pubmed: 29490248
Biochemistry. 2002 Nov 5;41(44):13143-51
pubmed: 12403615
Proteins. 2014 Nov;82(11):3032-42
pubmed: 25116395
Science. 2009 Dec 11;326(5959):1533-7
pubmed: 20007899
Biochemistry. 2018 May 29;57(21):3065-3074
pubmed: 29697253
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8628-32
pubmed: 3317417
Anal Biochem. 1989 Mar;177(2):244-9
pubmed: 2729542
Eur J Nutr. 2014 Sep;53(6):1327-33
pubmed: 24292746
Int Arch Allergy Immunol. 2010;153(4):359-66
pubmed: 20559001
Arch Biochem Biophys. 1968 Mar 20;124(1):18-26
pubmed: 5661599
Protein Sci. 2001 Sep;10(9):1775-84
pubmed: 11514668
Annu Rev Biochem. 2017 Jun 20;86:27-68
pubmed: 28498720
Proteins. 2013 Nov;81(11):1862-73
pubmed: 23760807
Biochem Biophys Res Commun. 2009 Apr 17;381(4):639-42
pubmed: 19248768
Neurosci Lett. 1997 Dec 12;239(1):45-8
pubmed: 9547168
Nat Protoc. 2016 Feb;11(2):252-72
pubmed: 26741409
Int J Cell Biol. 2013;2013:318319
pubmed: 23983694
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18990-5
pubmed: 19864624
Biomolecules. 2018 Mar 20;8(1):
pubmed: 29558422
Compr Physiol. 2011 Apr;1(2):941-69
pubmed: 23737208
Biochemistry. 2010 Sep 7;49(35):7748-55
pubmed: 20712299
J Mol Biol. 2008 Feb 8;376(1):258-68
pubmed: 18155723
Biochemistry. 1993 May 11;32(18):4693-7
pubmed: 8490014
Biochemistry. 2004 Dec 28;43(51):16076-85
pubmed: 15610002
Redox Biol. 2020 Jan;28:101316
pubmed: 31539802
Biochemistry. 2005 Oct 4;44(39):13063-70
pubmed: 16185074
Biochemistry. 2004 Jun 15;43(23):7365-81
pubmed: 15182180
Angew Chem Int Ed Engl. 2009;48(50):9452-6
pubmed: 19882604
Sci Rep. 2016 Sep 06;6:32801
pubmed: 27597317
Sci Rep. 2018 Apr 3;8(1):5465
pubmed: 29615738
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18663-8
pubmed: 19022905
Chem Rev. 2013 Jul 10;113(7):4633-79
pubmed: 23514336
J Neurosci. 2010 Oct 27;30(43):14411-9
pubmed: 20980598
Biophys Rev. 2017 Aug;9(4):329-338
pubmed: 28812278
ACS Chem Biol. 2014 Feb 21;9(2):378-82
pubmed: 24199868
Trends Microbiol. 2012 Feb;20(2):66-73
pubmed: 22197327
J Biochem. 2002 Jan;131(1):45-52
pubmed: 11754734