Investigating the NPY/AgRP/GABA to GnRH Neuron Circuit in Prenatally Androgenized PCOS-Like Mice.
HPG axis
hypothalamic-pituitary-gonadal axis
neuropeptide Y
steroid hormone receptors
tract-tracing
transgenic mouse
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
28
07
2020
accepted:
24
08
2020
entrez:
23
10
2020
pubmed:
24
10
2020
medline:
24
10
2020
Statut:
epublish
Résumé
Polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility, is associated with altered signaling within the hormone-sensitive neuronal network that regulates gonadotropin-releasing hormone (GnRH) neurons, leading to a pathological increase in GnRH secretion. Circuit remodeling is evident between GABAergic neurons in the arcuate nucleus (ARN) and GnRH neurons in a murine model of PCOS. One-third of ARN GABA neurons co-express neuropeptide Y (NPY), which has a known yet complex role in regulating GnRH neurons and reproductive function. Here, we investigated whether the NPY-expressing subpopulation (NPY
Identifiants
pubmed: 33094210
doi: 10.1210/jendso/bvaa129
pii: bvaa129
pmc: PMC7566551
doi:
Types de publication
Journal Article
Langues
eng
Pagination
bvaa129Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society.
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