Principal component analysis, a useful tool to study cyclin-dependent kinase-inhibitor's effect on cerebral ischaemia.
CDK inhibitor
NeuroVascular Unit
ischaemic stroke
oedema
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
04
2020
revised:
30
06
2020
accepted:
06
07
2020
entrez:
23
10
2020
pubmed:
24
10
2020
medline:
24
10
2020
Statut:
epublish
Résumé
Stroke is a leading cause of acute death related in part to brain oedema, blood-brain barrier disruption and glial inflammation. A cyclin-dependant kinase inhibitor, (S)-roscovitine, was administered 90 min after onset on a model of rat focal cerebral ischaemia. Brain swelling and Evans Blue tissue extravasation were quantified after Evans Blue injection. Combined tissue Evans Blue fluorescence and immunofluorescence of endothelial cells (RECA1), microglia (isolectin-IB4) and astrocytes (glial fibrillary acidic protein) were analysed. Using a Student's
Identifiants
pubmed: 33094284
doi: 10.1093/braincomms/fcaa136
pii: fcaa136
pmc: PMC7566348
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcaa136Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
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