Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report.


Journal

Journal of tropical pediatrics
ISSN: 1465-3664
Titre abrégé: J Trop Pediatr
Pays: England
ID NLM: 8010948

Informations de publication

Date de publication:
29 01 2021
Historique:
pubmed: 24 10 2020
medline: 21 5 2021
entrez: 23 10 2020
Statut: ppublish

Résumé

Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatric Unit of the University Hospital Center. The child was not immunized against diphtheria. A throat swab was performed and cultured, from which Corynebacterium diphtheriae was identified. The strain, of biovar Mitis, was confirmed as diphtheria toxin (DT)-gene positive and produced DT (Elek test). Unfortunately, the child developed cardiac and neurological complications and died of respiratory and heart failure.

Identifiants

pubmed: 33094342
pii: 5936080
doi: 10.1093/tropej/fmaa064
pii:
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : World Health Organization
ID : 001
Pays : International

Informations de copyright

© The Author(s) [2020]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Auteurs

Rivo Solotiana Rakotomalala (RS)

Laboratoire de Biologie médicale, Département de Sciences fondamentales, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar.

Zo Zafitsara Andrianirina (ZZ)

Département de Pédiatrie, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar.

Elisoa Ratsima (E)

Centre de Biologie Clinique, Institut Pasteur de Madagascar, 101 Antananarivo, Madagascar.

Patrick Randrianandraina (P)

Service ORL, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar.

Frédérique Randrianirina (F)

Centre de Biologie Clinique, Institut Pasteur de Madagascar, 101 Antananarivo, Madagascar.

Glenn Torrencelli Edosoa (GT)

Organisation Mondiale de la Santé, Bureau Pays de Madagascar, 101 Antananarivo, Madagascar.

Tahirimalala Rabenandrianina (T)

Laboratoire de Biologie médicale, Département de Sciences fondamentales, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar.

Edgar Badell (E)

Institut Pasteur, National Reference Center for Corynebacteria of the Diphtheriae Complex, 75015 Paris, France.
Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, 75015 Paris, France.

Julie Toubiana (J)

Institut Pasteur, National Reference Center for Corynebacteria of the Diphtheriae Complex, 75015 Paris, France.
Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, 75015 Paris, France.
Université de Paris, General Pediatrics and Pediatric infectious diseases department, Necker-Enfants malades, APHP, 75015, Paris, France.

Diavolana Andrianarimanana (D)

Département de Pédiatrie, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar.

Sylvain Brisse (S)

Institut Pasteur, National Reference Center for Corynebacteria of the Diphtheriae Complex, 75015 Paris, France.
Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, 75015 Paris, France.

Andry Rasamindrakotroka (A)

Laboratoire de Formation et de Recherche en Biologie Médicale, Faculté de Médecine, Université d'Antananarivo, 101 Antananarivo, Madagascar.

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Classifications MeSH