Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.
Aging
Cognitive impairment
Dementia
Radiation
WBI
WBRT
Whole brain radiation therapy
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
13
08
2020
accepted:
14
10
2020
pubmed:
24
10
2020
medline:
1
6
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
Whole brain irradiation (WBI) therapy is an important treatment for brain metastases and potential microscopic malignancies. WBI promotes progressive cognitive dysfunction in over half of surviving patients, yet, the underlying mechanisms remain obscure. Astrocytes play critical roles in the regulation of neuronal activity, brain metabolism, and cerebral blood flow, and while neurons are considered radioresistant, astrocytes are sensitive to γ-irradiation. Hallmarks of astrocyte function are the ability to generate stimulus-induced intercellular Ca
Identifiants
pubmed: 33094399
doi: 10.1007/s11357-020-00289-8
pii: 10.1007/s11357-020-00289-8
pmc: PMC8050172
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-212Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS056218
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047879
Pays : United States
Organisme : CIHR
ID : FDN-148471
Pays : Canada
Organisme : the Cellular and Molecular GeroScience CoBRE
ID : P20GM125528
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States
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