Justicia flava leaf extract potently relaxes pregnant human myometrial contractility: a lead plant for drug discovery of new tocolytic drugs.
Acanthaceae
extract
human uterus
justicia flava
myometrium
plant
preterm birth
preterm labour
spontaneous contraction
tocolytic
uterus
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
03
06
2020
accepted:
13
10
2020
pubmed:
24
10
2020
medline:
21
10
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
What is the central question of this study? Can Justicia flava leaf extract (JF) inhibit human myometrial contractility as was previously shown in mouse myometrium? What is the main finding and its importance? JF abolished human myometrial contractions and therefore presents as a lead plant in drug discovery studies involving drugs for preterm birth. In the search for new potent therapies for preterm labour, Justicia flava leaf extract (JF) was previously shown to potently inhibit uterine contractility in both pregnant and non-pregnant mouse uterus. This study took the investigation a step further and investigated the activity of JF on pregnant human myometrial contractility. JF potently inhibited human myometrial contractility in a concentration-dependent manner. This pilot study provides evidence that JF should be further investigated as a lead plant in the drug discovery of new uterine relaxants.
Substances chimiques
Pharmaceutical Preparations
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2033-2037Subventions
Organisme : Society for Reproductive Investigation
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
Références
Al-Omari, W. R., Al-Shammaa, H. B., Al-Tikriti, E. M., & Ahmed, K. W. (2006). Atosiban and nifedipine in acute tocolysis: a comparative study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 128(1-2), 129-134.
Anderson, L., Martin, W., Higgins, C., Nelson, S. M., & Norman, J. E. (2009). The effect of progesterone on myometrial contractility, potassium channels, and tocolytic efficacy. Reproductive Sciences, 16, 1052-1061.
Arrowsmith, S., Quenby, S., Weeks, A., Burdyga, T., & Wray, S. (2012). Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies. PLoS ONE, 7(5), e36787.
Bafor, E. E., Ukpebor, F., Elvis-offiah, U., Uchendu, A., Omoruyi, O., & Omogiade, G. U. (2020). Justicia flava leaves exert mild estrogenic activity in mouse models of uterotrophic and reproductive cycle investigations. Journal of Medicinal Food, 23(4), 395-408.
Bafor, E. E., Ukpebor, F., Omoruyi, O., Ochoyama, E., & Odega, K. (2019b). Acute toxicological evaluations of the methanol leaf extract of Justicia flava (Vahl) acanthaceae in mouse models. Tropical Journal of Natural Product Research, 3(4), 138-144.
Bafor, E. E., Ukpebor, F., Omoruyi, O., Ochoyama, E., Ekufu, J., & Edrada-Ebel, R. (2019a). Tocolytic activity assessment of the methanol leaf extract of Justicia flava Vahl (Acanthaceae) on mouse myometrial contractility and preliminary mass spectrometric determination of secondary metabolites. Journal of Ethnopharmacology, 243, 112087.
Berkman, N. D., Thorp, J. M., Lohr, K. N., Carey, T. S., Hartmann, K. E., Gavin, N. I., … Idicula, A. E. (2003). Tocolytic, treatment for the management of preterm labor: a review of the evidence. American Journal of Obstetrics and Gynecology, 188, 1648-1659.
Dodds, K. N., Staikopoulos, V., & Beckett, E. A. (2015). Uterine contractility in the nonpregnant mouse: changes during the estrous cycle and effects of chloride channel blockade. Biology of Reproduction, 92(6), 1-15.
Fanchin, R., Ayoubi, J. M., Olivennes, F., Righini, C., de Ziegler, D., & Frydman, R. (2000). Hormonal influence on the uterine contractility during ovarian stimulation. Hum Reprod, 15(Suppl 1), 90-100.
Fanchin, R., Righini, C., De Ziegler, D., Olivennes, F., Ledée, N., & Frydman, R. (2001). Effects of vaginal progesterone administration on uterine contractility at the time of embryo transfer. Fertility and Sterility, 75(6), 1136-1140.
Frey, A. H., & Klebanoff, A. M. (2016). The epidemiology, etiology, and costs of preterm birth. Seminars in Fetal and Neonatal Medicine, 21(2), 68-73.
Gwehenberger, B., Rist, L., Huch, R., & Von Mandach, U. (2004). Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. European Journal of Obstetrics and Gynecology and Reproductive Biology, 113, 164-171.
Hajagos-Tóth, J., Falkay, G., & Gáspár, R. (2009). Modification of the effect of nifedipine in the pregnant rat myometrium: the influence of progesterone and terbutaline. Life Sciences, 85(15-16), 568-572.
Liu, L., Oza, S., Hogan, D., Chu, Y., Perin, J., Zhu, J., … Black, R. E. (2016). Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. The Lancet, 388(10063), 3027-3035.
Luckas, M. J. M., & Wray, S. (2000). A comparison of the contractile properties of human myometrium obtained from the upper and lower uterine segments. British Journal of Obstetrics and Gynaecology, 107, 1309-1311.
Moynihan, A. T., Smith, T. J., & Morrison, J. J. (2008). The relaxant effect of nifedipine in human uterine smooth muscle and the BKCa channel. American Journal of Obstetrics and Gynecology, 198(2), 237.e1-237.e8.
Sanborn, B. M. (2001). Hormones and calcium: mechanisms controlling uterine smooth muscle contractile activity. Experimental Physiology, 86(2), 223-237.
Simões-Wüst, A. P., Lapaire, O., Hösli, I., Wächter, R., Fürer, K., Schnelle, M., … Von Mandach, U. (2018). Two randomised clinical trials on the use of bryophyllum pinnatum in preterm labour: results after early discontinuation. Complementary Medicine Research, 25(4), 269-273.
Sukwan, C., Wray, S., & Kupittayanant, S. (2014). The effects of Ginseng Java root extract on uterine contractility in nonpregnant rats. Physiological Reports, 2(12), e12230.
van Veen, A. J., Pelinck, M. J., van Pampus, M. G., & Erwich, J. J. (2005). Severe hypotension and fetal death due to tocolysis with nifedipine. BJOG, 112, 509-510.
van Vliet, E. O. G., Boormans, E. M., De Lange, T. S., Mol, B. W., & Oudijk, M. A. (2014). Preterm labor: current pharmacotherapy options for tocolysis. Expert Opinion on Pharmacotherapy, 15, 787-797.
Young, R. C., Schumann, R., & Zhang, P. (2001). Nifedipine block of capacitative calcium entry in cultured human uterine smooth-muscle cells. Journal of the Society for Gynecologic Investigation, 8, 210-215.