Association Between Immune Response to Cytomegalovirus and Cognition in the Health and Retirement Study.
Alzheimer disease and related dementias
cognitive decline
cytomegalovirus
educational attainment
immune function
Journal
American journal of epidemiology
ISSN: 1476-6256
Titre abrégé: Am J Epidemiol
Pays: United States
ID NLM: 7910653
Informations de publication
Date de publication:
04 05 2021
04 05 2021
Historique:
received:
21
06
2020
revised:
12
10
2020
accepted:
20
10
2020
pubmed:
24
10
2020
medline:
22
6
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
Chronic infections and the subsequent immune response have recently been shown to be risk factors for cognitive decline and Alzheimer disease and related dementias (ADRD). While some studies have shown an association between cytomegalovirus (CMV), a chronic and highly prevalent infection, and cognition and/or ADRD, these studies have been limited by nonrepresentative and small samples. Using 2016 data on 5,617 adults aged 65 years or more from the Health and Retirement Study, we investigated the cross-sectional associations of both CMV serostatus and immunoglobulin G (IgG) antibody response with cognitive function using linear regression models adjusting for age, sex, race/ethnicity, and educational attainment. We further investigated potential effect-measure modification by educational attainment. Overall, both CMV seropositivity and higher IgG antibody response were associated with lower cognitive function, though the relationship was not statistically significant in adjusted models. Among participants with less than a high school diploma, CMV seropositivity and being in the first tertile of IgG response, relative to seronegative persons, were associated with lower scores on the Telephone Interview for Cognitive Status (-0.56 points (95% confidence interval: -1.63, 0.52) and -0.89 points (95% confidence interval: -2.07, 0.29), respectively), and the relationship was attenuated among those with higher education. Our results suggest that CMV may be a risk factor for cognitive impairment, particularly among persons with fewer educational resources.
Identifiants
pubmed: 33094810
pii: 5936086
doi: 10.1093/aje/kwaa238
pmc: PMC8096487
doi:
Substances chimiques
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
786-797Subventions
Organisme : NIA NIH HHS
ID : K99 AG062749
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG062749
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057800
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD091058
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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