Intra-hematomal White Matter Tracts Act As a Scaffold for Macrophage Infiltration After Intracerebral Hemorrhage.
Intracerebral hemorrhage
Microglia/macrophages
Phagocytosis
White matter
Journal
Translational stroke research
ISSN: 1868-601X
Titre abrégé: Transl Stroke Res
Pays: United States
ID NLM: 101517297
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
09
09
2020
accepted:
18
10
2020
revised:
15
10
2020
pubmed:
24
10
2020
medline:
14
1
2022
entrez:
23
10
2020
Statut:
ppublish
Résumé
Intracerebral hemorrhage (ICH) is a stroke subtype with high mortality and severe morbidity. Hemorrhages frequently develop within the white matter, but whether white matter fibers within the hematoma survive after ICH has not been well studied. The current study examines whether white matter fibers persist in the hematoma after ICH, fibers that might be impacted by evacuation, and their relationship to macrophage infiltration in a porcine model. Male piglets had 2.5 ml blood with or without CD47 blocking antibody injected into the right frontal lobe. Brains were harvested from 3 days to 2 months after ICH for brain histology. White matter fibers were detected within the hematoma 3 and 7 days after hemorrhage by brain histology and myelin basic protein immunohistochemistry. White matter still remained in the hematoma cavity at 2 months after ICH. Macrophage scavenger receptor-1 positive macrophages/microglia and heme oxygenase-1 positive cells infiltrated into the hematoma along the intra-hematomal white matter fibers at 3 and 7 days after ICH. Treatment with CD47 blocking antibody enhanced the infiltration of these cells. In conclusion, white matter fibers exist within the hematoma after ICH and macrophages/microglia may use such fibers as a scaffold to infiltrate into the hematoma and aid in hematoma clearance.
Identifiants
pubmed: 33094829
doi: 10.1007/s12975-020-00870-5
pii: 10.1007/s12975-020-00870-5
pmc: PMC8060356
mid: NIHMS1640267
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
858-865Subventions
Organisme : NINDS NIH HHS
ID : NS116786
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS099684
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS108042
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS104663
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096917
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106746
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS112394
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS090925
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116786
Pays : United States
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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