RecQ helicases in DNA repair and cancer targets.
DNA damage
DNA synthesis and repair
protein structure
synthetic lethality
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
26 10 2020
26 10 2020
Historique:
received:
15
07
2020
revised:
01
09
2020
accepted:
10
09
2020
pubmed:
24
10
2020
medline:
8
6
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
Helicases are enzymes that use the energy derived from ATP hydrolysis to catalyze the unwinding of DNA or RNA. The RecQ family of helicases is conserved through evolution from prokaryotes to higher eukaryotes and plays important roles in various DNA repair pathways, contributing to the maintenance of genome integrity. Despite their roles as general tumor suppressors, there is now considerable interest in exploiting RecQ helicases as synthetic lethal targets for the development of new cancer therapeutics. In this review, we summarize the latest developments in the structural and mechanistic study of RecQ helicases and discuss their roles in various DNA repair pathways. Finally, we consider the potential to exploit RecQ helicases as therapeutic targets and review the recent progress towards the development of small molecules targeting RecQ helicases as cancer therapeutics.
Identifiants
pubmed: 33095241
pii: 226761
doi: 10.1042/EBC20200012
pmc: PMC7588665
doi:
Substances chimiques
RecQ Helicases
EC 3.6.4.12
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-830Informations de copyright
© 2020 The Author(s).
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