Cancer stem cells and strategies for targeted drug delivery.
Anti-tumor therapy
Cancer biology
Cancer stem cells (CSCs)
Drug delivery system
Drug-resistance
Journal
Drug delivery and translational research
ISSN: 2190-3948
Titre abrégé: Drug Deliv Transl Res
Pays: United States
ID NLM: 101540061
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
accepted:
01
10
2020
pubmed:
24
10
2020
medline:
8
4
2022
entrez:
23
10
2020
Statut:
ppublish
Résumé
Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.
Identifiants
pubmed: 33095384
doi: 10.1007/s13346-020-00863-9
pii: 10.1007/s13346-020-00863-9
pmc: PMC8062588
mid: NIHMS1640594
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1779-1805Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB019893
Pays : United States
Informations de copyright
© 2020. Controlled Release Society.
Références
Chem Commun (Camb). 2019 May 28;55(43):6106-6109
pubmed: 31070201
Sci Rep. 2016 Jul 29;6:30707
pubmed: 27469492
Clin Cancer Res. 2010 Jun 15;16(12):3141-52
pubmed: 20530696
Adv Healthc Mater. 2015 Aug 5;4(11):1675-80
pubmed: 26097122
Cell Stem Cell. 2011 May 6;8(5):482-5
pubmed: 21549324
Biomaterials. 2019 Apr;200:1-14
pubmed: 30743049
BMC Immunol. 2015 Jan 31;16:1
pubmed: 25636521
Cell Stem Cell. 2013 Mar 7;12(3):329-41
pubmed: 23333149
Leukemia. 2000 Oct;14(10):1777-84
pubmed: 11021753
Cancer Chemother Pharmacol. 2015 May;75(5):879-86
pubmed: 25424280
Hum Genomics. 2009 Apr;3(3):281-90
pubmed: 19403462
Cancer Res. 1996 Oct 1;56(19):4332-7
pubmed: 8813118
Front Biosci (Elite Ed). 2017 Jan 1;9:162-173
pubmed: 27814597
Sci Rep. 2019 Aug 28;9(1):12492
pubmed: 31462656
Tumour Biol. 2015 Sep;36(9):7107-19
pubmed: 25877753
Cancer Lett. 2016 Oct 1;380(2):561-567
pubmed: 25979233
Mol Pharmacol. 2019 Apr;95(4):418-432
pubmed: 30737252
J Neuropathol Exp Neurol. 2016 May;75(5):388-96
pubmed: 26979081
Stem Cells. 2009 May;27(5):1006-20
pubmed: 19415765
Semin Cancer Biol. 2016 Oct;40-41:192-208
pubmed: 27609747
Mol Ther. 2011 Aug;19(8):1538-46
pubmed: 21629222
Trends Pharmacol Sci. 2015 Jun;36(6):374-83
pubmed: 25857287
Front Oncol. 2020 Jan 17;9:1482
pubmed: 32010611
Int J Cancer. 2012 Jan 1;130(1):29-39
pubmed: 21480217
Biomaterials. 2014 Nov;35(33):9177-86
pubmed: 25106770
Curr Pharm Des. 2012;18(19):2838-49
pubmed: 22390767
Theranostics. 2014 Jun 10;4(8):845-57
pubmed: 24955145
Int J Biochem Cell Biol. 2018 Oct;103:115-124
pubmed: 30153480
J Natl Cancer Inst. 1993 Mar 17;85(6):478-83
pubmed: 8095304
Neoplasma. 2017;64(1):81-91
pubmed: 27881008
Theranostics. 2020 Jan 1;10(3):1181-1196
pubmed: 31938059
J Control Release. 2019 Feb 10;295:268-277
pubmed: 30639386
J Mater Chem B. 2019 Mar 28;7(12):2054-2062
pubmed: 32254809
Biomaterials. 2018 Jan;152:47-62
pubmed: 29107218
Cell Stem Cell. 2014 Mar 6;14(3):342-56
pubmed: 24607406
Dig Dis Sci. 2011 Mar;56(3):741-50
pubmed: 20683663
Ann Surg Oncol. 2012 Jul;19 Suppl 3:S539-48
pubmed: 21879266
Angew Chem Int Ed Engl. 2018 Jan 2;57(1):287-291
pubmed: 29144008
Cancer Cell. 2008 Sep 9;14(3):238-49
pubmed: 18772113
J Control Release. 2009 May 21;136(1):21-9
pubmed: 19331851
J Mater Chem B. 2017 Sep 7;5(33):6762-6775
pubmed: 32264326
Int Rev Immunol. 2019;38(6):267-283
pubmed: 31578892
Br J Cancer. 2007 Feb 12;96(3):417-23
pubmed: 17211480
Cancer Res. 2008 Mar 1;68(5):1485-94
pubmed: 18316613
Cell Cycle. 2009 Oct 15;8(20):3274-84
pubmed: 19770585
Cancer Lett. 2009 May 8;277(1):1-7
pubmed: 18809245
Front Pharmacol. 2016 Aug 12;7:244
pubmed: 27570510
Nat Rev Drug Discov. 2006 Mar;5(3):219-34
pubmed: 16518375
Development. 2014 Sep;141(18):3445-57
pubmed: 25183867
Cancer Lett. 2017 Jan 28;385:87-96
pubmed: 27816488
PLoS One. 2008;3(11):e3655
pubmed: 18985161
Small. 2018 Jun 21;:e1800785
pubmed: 29931728
Br J Cancer. 2010 Aug 10;103(4):439-45
pubmed: 20664590
J Cell Physiol. 2012 Feb;227(2):421-30
pubmed: 21448925
Clin Cancer Res. 2006 Nov 1;12(21):6565-72
pubmed: 17085672
Expert Opin Biol Ther. 2017 Mar;17(3):313-324
pubmed: 27960589
J Immunother. 2018 Oct;41(8):361-368
pubmed: 30063587
Hepatology. 2015 Feb;61(2):598-612
pubmed: 25307947
Bioessays. 2016 Jul;38 Suppl 1:S65-74
pubmed: 27417124
Curr Biol. 2007 Jan 23;17(2):165-72
pubmed: 17196391
Biochem Pharmacol. 2012 Nov 1;84(9):1154-63
pubmed: 22902833
Int J Nanomedicine. 2010 Aug 09;5:437-44
pubmed: 20957165
Int J Mol Sci. 2017 Apr 25;18(5):
pubmed: 28441355
Int J Mol Sci. 2018 Mar 01;19(3):
pubmed: 29494563
Mol Cancer. 2020 Feb 6;19(1):27
pubmed: 32028963
Stem Cells. 2014 Jun;32(6):1380-9
pubmed: 24497003
Drug Deliv Transl Res. 2013 Apr;3(2):121-42
pubmed: 25787981
Am J Cancer Res. 2015 Feb 15;5(3):894-906
pubmed: 26045976
Adv Cancer Res. 2014;122:1-67
pubmed: 24974178
J Control Release. 2020 Apr 10;320:96-104
pubmed: 31931052
Mol Ther. 2016 May;24(5):926-36
pubmed: 26916284
MAbs. 2009 Jan-Feb;1(1):12-25
pubmed: 20046569
Biomaterials. 2012 Feb;33(6):1808-20
pubmed: 22136714
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8
pubmed: 12629218
J Cell Mol Med. 2009 Sep;13(9B):4023-33
pubmed: 20196789
Bioconjug Chem. 1996 Mar-Apr;7(2):209-16
pubmed: 8983343
Blood. 2012 Jun 28;119(26):6198-208
pubmed: 22286199
Cancer Res. 2003 Sep 15;63(18):5821-8
pubmed: 14522905
Biochim Biophys Acta Mol Basis Dis. 2017 Jul;1863(7):1728-1738
pubmed: 28502706
Pancreas. 1994 Nov;9(6):748-52
pubmed: 7531334
Acta Pharmacol Sin. 2016 Dec;37(12):1606-1622
pubmed: 27840408
Sci Rep. 2018 Aug 13;8(1):12042
pubmed: 30104575
Int J Pharm. 2017 Aug 7;528(1-2):322-333
pubmed: 28606508
Mol Pharm. 2009 May-Jun;6(3):928-39
pubmed: 19278222
FEBS Lett. 2006 May 22;580(12):2903-9
pubmed: 16497299
Front Biosci (Schol Ed). 2012 Jan 01;4:277-86
pubmed: 22202060
Nat Rev Drug Discov. 2009 Jul;8(7):579-91
pubmed: 19478820
Cancer Res. 2008 Jun 1;68(11):4311-20
pubmed: 18519691
Folia Histochem Cytobiol. 2001;39 Suppl 2:152-3
pubmed: 11820582
Int J Pharm. 2015 May 15;485(1-2):50-60
pubmed: 25712164
Nat Cell Biol. 2014 Nov;16(11):1105-17
pubmed: 25266422
Life Sci. 2019 Oct 1;234:116781
pubmed: 31430455
Eur J Clin Invest. 2007 Jan;37(1):73-82
pubmed: 17181570
Cancer Res Treat. 2017 Oct;49(4):1140-1152
pubmed: 28231426
Gastroenterology. 2007 Jun;132(7):2542-56
pubmed: 17570225
Cell Cycle. 2011 Nov 15;10(22):3871-85
pubmed: 22127234
Stem Cells. 2007 Oct;25(10):2524-33
pubmed: 17628016
Cancer Res. 2005 May 15;65(10):4320-33
pubmed: 15899824
Pharmgenomics Pers Med. 2014 Feb 05;7:53-64
pubmed: 24523596
Semin Oncol. 2015 Apr;42 Suppl 1:S3-17
pubmed: 25839664
Stem Cells Int. 2016;2016:5285892
pubmed: 27840647
Nat Med. 1997 Jul;3(7):730-7
pubmed: 9212098
Mol Pharm. 2014 Aug 4;11(8):2703-12
pubmed: 24960465
J Med Chem. 2005 Jun 2;48(11):3768-75
pubmed: 15916428
Cancer Cell. 2015 Oct 12;28(4):441-455
pubmed: 26461092
J Biol Chem. 2008 Jun 20;283(25):17635-51
pubmed: 18441325
Drug Resist Updat. 2010 Aug-Oct;13(4-5):109-18
pubmed: 20692200
Leuk Res. 2014 Nov;38(11):1299-308
pubmed: 25262448
Oncoimmunology. 2018 Apr 18;7(8):e1450710
pubmed: 30221040
Adv Mater. 2014 Apr 23;26(16):2566-71
pubmed: 24532221
Stem Cell Investig. 2019 Aug 05;6:21
pubmed: 31559308
J Control Release. 2017 Nov 28;266:166-186
pubmed: 28941992
Oncotarget. 2016 Dec 13;7(50):83502-83513
pubmed: 27835872
Oncogene. 2011 Nov 17;30(46):4609-21
pubmed: 21643013
Clin Cancer Res. 2015 Feb 1;21(3):505-13
pubmed: 25646180
Biomaterials. 2014 May;35(16):4667-77
pubmed: 24630839
Biomaterials. 2012 Jan;33(2):565-82
pubmed: 21983136
Clin Cancer Res. 2002 Jan;8(1):22-8
pubmed: 11801536
Semin Cancer Biol. 2018 Dec;53:139-155
pubmed: 30081228
Biomaterials. 2013 Sep;34(29):7191-203
pubmed: 23806972
J Leukoc Biol. 1999 Feb;65(2):151-61
pubmed: 10088597
Cancer Lett. 2003 Mar 20;192(1):75-82
pubmed: 12637155
Int J Cancer. 2009 Aug 1;125(3):717-22
pubmed: 19431142
Cancer Res. 1996 Aug 15;56(16):3626-9
pubmed: 8705995
Oncol Lett. 2019 Dec;18(6):5897-5904
pubmed: 31788063
Genes Dev. 2007 Nov 15;21(22):2861-73
pubmed: 18006683
Blood. 2004 Mar 15;103(6):2332-6
pubmed: 14630803
Environ Health Perspect. 1993 Dec;101 Suppl 5:15-26
pubmed: 7516873
Acta Biomater. 2018 Sep 15;78:296-307
pubmed: 30099198
Biotechnol Adv. 2013 Dec;31(8):1397-407
pubmed: 23800690
J Biomed Nanotechnol. 2016 Jul;12(7):1463-77
pubmed: 29337484
Int J Cancer. 2017 Oct 1;141(7):1402-1412
pubmed: 28614911
Drug Discov Today. 2017 Jun;22(6):952-959
pubmed: 28435061
Semin Cancer Biol. 2020 Feb;60:166-180
pubmed: 31369817
Nature. 2004 Nov 18;432(7015):396-401
pubmed: 15549107
Biochem Biophys Res Commun. 2010 Apr 16;394(4):1098-104
pubmed: 20350531
Clin Transl Med. 2018 Jul 9;7(1):18
pubmed: 29984391
Semin Cancer Biol. 2017 Dec;47:18-28
pubmed: 28673608
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):973-8
pubmed: 17210912
Bioconjug Chem. 2015 Jul 15;26(7):1307-13
pubmed: 25343502
Drug Deliv Transl Res. 2013 Apr;3(2):195-204
pubmed: 25787984
Biomaterials. 2016 Oct;103:44-55
pubmed: 27376558
Cancer Sci. 2016 Jan;107(1):5-11
pubmed: 26362755
Neoplasia. 2019 Aug;21(8):822-836
pubmed: 31299607
Front Oncol. 2014 Jan 13;3:327
pubmed: 24455486
Cancer Res. 2001 Mar 15;61(6):2592-601
pubmed: 11289136
Future Drug Discov. 2019 Jul 01;1(1):FDD8
pubmed: 31448368
Biochem Biophys Res Commun. 2006 Dec 29;351(4):820-4
pubmed: 17097610
ACS Nano. 2018 Nov 27;12(11):11600-11609
pubmed: 30380832
J Drug Target. 2018 Sep;26(8):649-657
pubmed: 29169275
World J Stem Cells. 2015 Jan 26;7(1):27-36
pubmed: 25621103
J Thorac Dis. 2017 Feb;9(2):E168-E174
pubmed: 28275508
Adv Sci (Weinh). 2018 Oct 29;5(12):1801012
pubmed: 30581704
Mol Pharmacol. 2009 Jun;75(6):1374-9
pubmed: 19270061
J Control Release. 2018 Jan 10;269:245-257
pubmed: 29162480
Int J Pharm. 2017 May 25;523(2):490-505
pubmed: 27940172
Clin Cancer Res. 2010 Jun 15;16(12):3130-40
pubmed: 20530699
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11008-13
pubmed: 17576927
Clin Dev Immunol. 2012;2012:708036
pubmed: 22693526
J Clin Invest. 2010 Sep;120(9):3326-39
pubmed: 20697159
Mol Cell. 2014 Jun 5;54(5):716-27
pubmed: 24905005
Cancer Biomark. 2016;16(3):301-7
pubmed: 27062695
Stem Cell Res Ther. 2018 May 21;9(1):144
pubmed: 29784015
Adv Mater. 2014 Oct 8;26(37):6401-8
pubmed: 25123089
J Immunol Methods. 2010 Sep 30;361(1-2):110-5
pubmed: 20674577
N Engl J Med. 2013 May 30;368(22):2059-74
pubmed: 23634996
Int J Oncol. 2015 Jan;46(1):215-22
pubmed: 25334080
Int J Oncol. 2012 Nov;41(5):1707-14
pubmed: 22923052
Semin Cancer Biol. 2017 Jun;44:25-42
pubmed: 28323021
J Cell Physiol. 2017 Aug;232(8):2008-2018
pubmed: 28019667
J Hepatol. 2010 Feb;52(2):280-1
pubmed: 20006402
Cancer Res. 2012 Oct 1;72(19):5048-59
pubmed: 22875023
Cancer Res. 2005 Dec 1;65(23):10946-51
pubmed: 16322242
Curr Drug Targets. 2006 Jul;7(7):893-909
pubmed: 16842220
Cell Death Differ. 2008 Mar;15(3):504-14
pubmed: 18049477
Int J Cancer. 2011 Dec 1;129(11):2720-31
pubmed: 21384342
Cancer Lett. 2013 Oct 1;339(1):70-81
pubmed: 23879969
Trends Cancer. 2017 May;3(5):372-386
pubmed: 28718414
Nat Rev Cancer. 2012 Jan 12;12(2):133-43
pubmed: 22237392
Cancer Lett. 2015 May 1;360(2):177-86
pubmed: 25676692
Exp Hematol Oncol. 2012 Nov 29;1(1):36
pubmed: 23210908
Nat Rev Cancer. 2008 Oct;8(10):755-68
pubmed: 18784658
Cancer Res. 2005 Oct 15;65(20):9328-37
pubmed: 16230395
Leuk Lymphoma. 2004 Aug;45(8):1501-10
pubmed: 15370200
Stem Cells Int. 2019 Nov 12;2019:9618065
pubmed: 31781251
Nat Rev Drug Discov. 2014 Jul;13(7):497-512
pubmed: 24981363
Curr Pharm Des. 2015;21(42):6236-45
pubmed: 26503142
Cell Rep. 2017 Dec 5;21(10):2813-2828
pubmed: 29212028
Adv Sci (Weinh). 2018 Apr 15;5(6):1700964
pubmed: 29938175
Acta Pharm Sin B. 2017 Jan;7(1):38-51
pubmed: 28119807
Biomaterials. 2014 Jan;35(3):1096-108
pubmed: 24183698
Adv Drug Deliv Rev. 2017 Oct 1;120:89-107
pubmed: 28736304
J Control Release. 2017 Jan 10;245:81-94
pubmed: 27863995
J Clin Invest. 2007 May;117(5):1195-203
pubmed: 17476349
BMC Cancer. 2016 Aug 02;16:581
pubmed: 27484993
Int J Nanomedicine. 2016 Aug 02;11:3655-75
pubmed: 27536105
Int J Nanomedicine. 2009;4:201-8
pubmed: 19918366
Oncogene. 2013 Feb 7;32(6):699-712
pubmed: 22525272
Free Radic Res. 2010 May;44(5):479-96
pubmed: 20370557
Cell Metab. 2015 Oct 6;22(4):590-605
pubmed: 26365176
Front Pharmacol. 2016 Apr 12;7:84
pubmed: 27148051
J Control Release. 1998 Apr 30;53(1-3):93-103
pubmed: 9741917
Cancer Immunol Res. 2018 Mar;6(3):358-369
pubmed: 29371260
Stem Cells. 2010 Jan;28(1):5-16
pubmed: 19904829
Eur J Med Chem. 2018 Aug 5;156:747-759
pubmed: 30048924
Drug Resist Updat. 1999 Dec;2(6):351-357
pubmed: 11498350
J Control Release. 2013 Nov 10;171(3):280-7
pubmed: 23871962
Oncogene. 2013 Feb 14;32(7):805-18
pubmed: 22508478
Vasc Cell. 2012 Apr 09;4:7
pubmed: 22487493
Cancers (Basel). 2010 May 17;2(2):859-84
pubmed: 24281098
Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9
pubmed: 17050692
Chembiochem. 2018 Nov 2;19(21):2246-2253
pubmed: 30109911
Med Oncol. 2011 Mar;28(1):105-11
pubmed: 20041317
Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1864-1871
pubmed: 29082764
Nature. 1985 Aug 29-Sep 4;316(6031):817-9
pubmed: 2863759
J Cell Mol Med. 2011 May;15(5):1013-31
pubmed: 21155971
Oncogene. 2018 May;37(18):2367-2378
pubmed: 29445137
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Jan;10(1):
pubmed: 28294555
Blood. 2017 Nov 30;130(22):2373-2376
pubmed: 29021230
Nature. 1985 Aug 29-Sep 4;316(6031):820-3
pubmed: 2412130
Int J Nanomedicine. 2018 Oct 25;13:6855-6870
pubmed: 30498347
Cell Stem Cell. 2010 Jun 4;6(6):603-15
pubmed: 20569697
J Pathol. 2019 Apr;247(5):708-718
pubmed: 30570140
Cancer Cell. 2012 Mar 20;21(3):283-96
pubmed: 22439924
Eur J Pharmacol. 2016 Jan 15;771:130-8
pubmed: 26689625
Genes Dev. 2012 Sep 1;26(17):1926-44
pubmed: 22899010
Nature. 1994 Feb 17;367(6464):645-8
pubmed: 7509044
Lung Cancer. 2009 Dec;66(3):275-81
pubmed: 19716622
Oncol Rep. 2015 Feb;33(2):515-25
pubmed: 25435189
Exp Toxicol Pathol. 2010 Sep;62(5):577-82
pubmed: 19758794
J Biosci. 2019 Jun;44(2):
pubmed: 31180052
Clin Exp Pharmacol Physiol. 2017 May;44(5):602-604
pubmed: 28107571
Adv Drug Deliv Rev. 2013 Nov;65(13-14):1686-98
pubmed: 24055719
Nature. 2009 Apr 9;458(7239):780-3
pubmed: 19194462
Am J Transl Res. 2016 Sep 15;8(9):3986-3994
pubmed: 27725879
Cancer Res. 2006 Oct 1;66(19):9339-44
pubmed: 16990346
J Drug Target. 2019 Mar;27(3):257-269
pubmed: 29911902
Oncogenesis. 2017 Jan 23;6(1):e291
pubmed: 28112719
Chem Sci. 2017 Jan 1;8(1):63-77
pubmed: 28451149
Br J Cancer. 2016 Jun 14;114(12):1305-12
pubmed: 27219018
Biomaterials. 2016 Mar;82:48-59
pubmed: 26751819
Cancer Cell. 2011 Mar 8;19(3):387-400
pubmed: 21397861
N Engl J Med. 2013 May 9;368(19):1845-6
pubmed: 23656658
Cancers (Basel). 2019 Jun 21;11(6):
pubmed: 31234336
EMBO J. 2012 May 2;31(9):2103-16
pubmed: 22446391
Oncotarget. 2015 Feb 28;6(6):3553-62
pubmed: 25708684
Cancers (Basel). 2019 Mar 05;11(3):
pubmed: 30841635
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7788-E7797
pubmed: 27849617
Antioxid Redox Signal. 2012 Jun 1;16(11):1215-28
pubmed: 22316005
PLoS One. 2014 Jun 23;9(6):e99412
pubmed: 24955581
Cell Stem Cell. 2015 Mar 5;16(3):225-38
pubmed: 25748930
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4048-53
pubmed: 17360475
PLoS One. 2015 Aug 25;10(8):e0136694
pubmed: 26305906
Nat Commun. 2015 Jan 23;6:5988
pubmed: 25612916
Am J Cancer Res. 2015 Feb 15;5(3):880-93
pubmed: 26045975
Oncogenesis. 2015 Nov 30;4:e177
pubmed: 26619402
Breast Cancer Res Treat. 2006 Sep;99(1):9-17
pubmed: 16752223
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14016-21
pubmed: 19666525
Int J Nanomedicine. 2015 Sep 10;10(Spec Iss):251-60
pubmed: 26425092
Oncogene. 2011 Jan 13;30(2):142-52
pubmed: 20838378
Nature. 2007 Jan 4;445(7123):106-10
pubmed: 17122772
Mol Cancer. 2013 Dec 23;12(1):171
pubmed: 24359639
Front Oncol. 2018 Aug 28;8:347
pubmed: 30211124
Acta Pharm Sin B. 2017 Jan;7(1):65-72
pubmed: 28119810
Int J Mol Sci. 2016 Dec 12;17(12):
pubmed: 27973444
Oncol Rep. 2016 Feb;35(2):978-84
pubmed: 26717967
Anticancer Res. 2017 May;37(5):2541-2547
pubmed: 28476825
Nature. 2006 May 25;441(7092):475-82
pubmed: 16598206
Oncogene. 2013 May 2;32(18):2261-72, 2272e.1-11
pubmed: 22733132
Biomaterials. 2016 Jul;93:1-9
pubmed: 27060212
Free Radic Biol Med. 2019 Mar;133:216-220
pubmed: 30040994
Stem Cells. 2020 Jan;38(1):6-14
pubmed: 31648395
Cancer Res. 2000 Jan 1;60(1):47-50
pubmed: 10646850
Small. 2019 Sep;15(36):e1902118
pubmed: 31328882
Sci Rep. 2018 Jan 17;8(1):967
pubmed: 29343829
Biomaterials. 2012 Feb;33(6):1863-72
pubmed: 22138033
Int J Mol Sci. 2018 Sep 11;19(9):
pubmed: 30208561
Mol Cancer Ther. 2011 Oct;10(10):1829-38
pubmed: 21862685
Nat Rev Clin Oncol. 2011 Feb;8(2):97-106
pubmed: 21151206
Adv Drug Deliv Rev. 2016 Feb 1;97:280-301
pubmed: 26686425
FEMS Microbiol Rev. 2003 Apr;27(1):75-97
pubmed: 12697343
Semin Radiat Oncol. 2019 Jan;29(1):42-54
pubmed: 30573183
Breast Cancer Res. 2016 May 24;18(1):55
pubmed: 27220421
J Appl Toxicol. 2011 Mar;31(2):164-72
pubmed: 20865757
Biomaterials. 2013 Jun;34(18):4452-65
pubmed: 23518403
Cancer Lett. 2013 Mar 1;330(1):84-95
pubmed: 23196060
Oncotarget. 2015 Oct 13;6(31):30472-86
pubmed: 26421710
G Chir. 2014 Nov-Dec;35(11-12):257-9
pubmed: 25644725
Drug Deliv Transl Res. 2013 Apr;3(2):143-51
pubmed: 25787982
Onco Targets Ther. 2015 Oct 16;8:2973-80
pubmed: 26527883
J Control Release. 1998 Jul 31;54(2):223-33
pubmed: 9724909
Cancer Res. 2007 Feb 1;67(3):1030-7
pubmed: 17283135
J Biomed Mater Res A. 2019 Feb;107(2):383-391
pubmed: 30350390
Mol Cancer Ther. 2012 Jan;11(1):165-73
pubmed: 22027695
Biochem Soc Trans. 2014 Oct;42(5):1372-7
pubmed: 25233417
Tumour Biol. 2014 May;35(5):3945-51
pubmed: 24420150
J Neurosci. 2014 Jun 18;34(25):8585-93
pubmed: 24948812
Oncotarget. 2016 May 31;7(22):33055-68
pubmed: 27102300
Nat Rev Cancer. 2010 Feb;10(2):147-56
pubmed: 20075923
Biomed Pharmacother. 2017 Dec;96:396-403
pubmed: 29031197
Stem Cells Transl Med. 2015 Sep;4(9):1033-43
pubmed: 26136504
Front Endocrinol (Lausanne). 2018 Mar 06;9:69
pubmed: 29559954
Anticancer Agents Med Chem. 2017 Nov 24;17(11):1466-1476
pubmed: 29034843
Cell Death Differ. 2019 Mar;26(4):690-702
pubmed: 30728463
J Exp Clin Cancer Res. 2018 Oct 3;37(1):240
pubmed: 30285798
J Clin Invest. 1998 Oct 15;102(8):1599-608
pubmed: 9788974
Stem Cells Dev. 2013 Aug 15;22(16):2221-39
pubmed: 23540661
Int J Cancer. 2011 Aug 15;129(4):820-31
pubmed: 21520032
Cancer Lett. 1994 Jan 15;76(1):63-9
pubmed: 7510214
Onco Targets Ther. 2013 Sep 06;6:1249-59
pubmed: 24043949
Best Pract Res Clin Haematol. 2009 Dec;22(4):577-82
pubmed: 19959110
Blood. 2014 Jun 19;123(25):3951-62
pubmed: 24778155
Clin Cancer Res. 2000 Aug;6(8):3046-55
pubmed: 10955783
J Immunother Cancer. 2016 Apr 19;4:19
pubmed: 27096096
Cell Stem Cell. 2011 Oct 4;9(4):298-310
pubmed: 21982230
Biomaterials. 2011 Aug;32(24):5673-87
pubmed: 21550109
Gene Ther. 2010 Nov;17(11):1363-71
pubmed: 20520650
J Mammary Gland Biol Neoplasia. 2009 Mar;14(1):3-9
pubmed: 19224345
Biochem Biophys Res Commun. 2011 Jan 14;404(2):735-42
pubmed: 21163253
J Control Release. 2018 Oct 28;288:62-83
pubmed: 30184466
Nanomedicine. 2015 Nov;11(8):2061-70
pubmed: 26199979
Biomaterials. 2014 Jan;35(2):836-45
pubmed: 24144908
Sci Rep. 2015 Jul 23;5:12465
pubmed: 26202299
Biomaterials. 2015 Nov;70:71-83
pubmed: 26302232
Nat Rev Cancer. 2017 Dec;17(12):738-750
pubmed: 29123246
Chem Biol Drug Des. 2014 Jun;83(6):741-52
pubmed: 24444042
Small. 2018 Apr;14(14):e1704245
pubmed: 29460335
Free Radic Biol Med. 2017 Mar;104:144-164
pubmed: 28088622