The impact of lockdown enforcement during the SARSCoV-2 pandemic on the timing of presentation and early outcomes of patients with ST-elevation myocardial infarction.
Aged
COVID-19
/ epidemiology
Communicable Disease Control
/ standards
Female
Humans
Israel
/ epidemiology
Length of Stay
/ statistics & numerical data
Male
Middle Aged
Pandemics
/ prevention & control
Patient Admission
/ standards
Patient Discharge
/ statistics & numerical data
Percutaneous Coronary Intervention
/ statistics & numerical data
Prospective Studies
Registries
/ statistics & numerical data
SARS-CoV-2
/ pathogenicity
ST Elevation Myocardial Infarction
/ diagnosis
Time Factors
Time-to-Treatment
/ statistics & numerical data
Treatment Outcome
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
08
2020
accepted:
08
10
2020
entrez:
23
10
2020
pubmed:
24
10
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Early reports described decreased admissions for acute cardiovascular events during the SarsCoV-2 pandemic. We aimed to explore whether the lockdown enforced during the SARSCoV-2 pandemic in Israel impacted the characteristics of presentation, reperfusion times, and early outcomes of ST-elevation myocardial infarction (STEMI) patients. A multicenter prospective cohort comprising all STEMI patients treated by primary percutaneous coronary intervention admitted to four high-volume cardiac centers in Israel during lockdown (20/3/2020-30/4/2020). STEMI patients treated during the same period in 2019 served as controls. The study comprised 243 patients, 107 during the lockdown period of 2020 and 136 during the same period in 2019, with no difference in demographics and clinical characteristics. Patients admitted in 2020 had higher admission and peak troponin levels, had a 2.4 fold greater likelihood of Door-to-balloon times> 90 min (95%CI: 1.2-4.9, p = 0.01) and 3.3 fold greater likelihood of pain-to-balloon times> 12 hours (OR 3.3, 95%CI: 1.3-8.1, p<0.01). They experienced higher rates hemodynamic instability (25.2% vs 14.7%, p = 0.04), longer hospital stay (median, IQR [4, 3-6 Vs 5, 4-6, p = 0.03]), and fewer early (<72 hours) discharge (12.4% Vs 32.4%, p<0.001). The lockdown imposed during the SARSCoV-2 pandemic was associated with a significant lag in the time to reperfusion of STEMI patients. Measures to improves this metric should be implemented during future lockdowns.
Identifiants
pubmed: 33095801
doi: 10.1371/journal.pone.0241149
pii: PONE-D-20-24693
pmc: PMC7584161
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0241149Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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