Relocation of an Extrasynaptic GABA

Animals Excitatory Postsynaptic Potentials / physiology Female Hippocampus / metabolism Inhibitory Postsynaptic Potentials / physiology Male Memory / physiology Mice Mice, Inbred C57BL Mice, Transgenic Neuronal Plasticity / physiology Receptors, GABA-A / genetics Reversal Learning / physiology Synapses / genetics
GABA receptors LTP learning memory metaplasticity optogenetic pharmacology synaptic plasticity ɑ5-GABARs

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
06 01 2021
Historique:
received: 19 05 2020
revised: 21 08 2020
accepted: 25 09 2020
pubmed: 24 10 2020
medline: 10 2 2021
entrez: 23 10 2020
Statut: ppublish

Résumé

The excitatory synapse between hippocampal CA3 and CA1 pyramidal neurons exhibits long-term potentiation (LTP), a positive feedback process implicated in learning and memory in which postsynaptic depolarization strengthens synapses, promoting further depolarization. Without mechanisms for interrupting positive feedback, excitatory synapses could strengthen inexorably, corrupting memory storage. Here, we reveal a hidden form of inhibitory synaptic plasticity that prevents accumulation of excitatory LTP. We developed a knockin mouse that allows optical control of endogenous α5-subunit-containing γ-aminobutyric acid (GABA)

Identifiants

DOI: 10.1016/j.neuron.2020.09.037 PMID: 33096025 PMC: PMC7790995
pubmed: 33096025
pii: S0896-6273(20)30761-3
doi: 10.1016/j.neuron.2020.09.037
pmc: PMC7790995
mid: NIHMS1635328
pii:
doi:

Substances chimiques

Receptors, GABA-A 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

123-134.e4

Subventions

Organisme : NEI NIH HHS
ID : P30 EY003176
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042889
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024334
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100911
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Christopher M Davenport (CM)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Rajit Rajappa (R)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Ljudmila Katchan (L)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Charlotte R Taylor (CR)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Ming-Chi Tsai (MC)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Caleb M Smith (CM)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Johannes W de Jong (JW)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Don B Arnold (DB)

Department of Biology, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.

Stephan Lammel (S)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Richard H Kramer (RH)

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rhkramer@berkeley.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques inhibiteurs › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage inversé › Relocation of an Extrasynaptic GABA
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Relocation of an Extrasynaptic GABA