Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.

Azepines / chemistry Calcitonin Gene-Related Peptide Receptor Antagonists / chemistry Dose-Response Relationship, Drug Humans Indazoles / chemistry Molecular Structure Receptors, Calcitonin Gene-Related Peptide / metabolism Structure-Activity Relationship
Calcitonin gene-related peptide Caprolactam Indazole Migraine

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
01 01 2021
Historique:
received: 08 07 2020
revised: 09 10 2020
accepted: 14 10 2020
pubmed: 24 10 2020
medline: 23 7 2021
entrez: 23 10 2020
Statut: ppublish

Résumé

Calcitonin gene-related peptide (CGRP) receptor antagonists have been shown clinically to be effective treatments for migraine. Zavegepant (BHV-3500, BMS-742413) is a high affinity antagonist of the CGRP receptor (hCGRP K

Identifiants

DOI: 10.1016/j.bmcl.2020.127624 PMID: 33096162
pubmed: 33096162
pii: S0960-894X(20)30735-6
doi: 10.1016/j.bmcl.2020.127624
pii:
doi:

Substances chimiques

Azepines 0
Calcitonin Gene-Related Peptide Receptor Antagonists 0
Indazoles 0
Receptors, Calcitonin Gene-Related Peptide 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

127624

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Stephen E Mercer (SE)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Bristol Myers Squibb, Cambridge, MA 02142, United States. Electronic address: stephen.mercer@bms.com.

Prasad V Chaturvedula (PV)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Spectrum Pharmaceuticals, Irvine, CA 92618, United States.

Charles M Conway (CM)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Biohaven Pharmaceuticals Inc., New Haven, CT 06510, United States.

Deborah A Cook (DA)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Medtronic, North Haven, CT 06473, United States.

Carl D Davis (CD)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Amgen, Inc. Thousand Oaks, CA 91320, United States.

Sokhom S Pin (SS)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Cerevel Therapeutics Cambridge, MA 02141, United States.

Robert Macci (R)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Thermo Fisher Scientific, Branford, CT 06405, United States.

Richard Schartman (R)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Preformulation Solutions, LLC. North Ridgeville, OH 44039, United States.

Laura J Signor (LJ)

Bristol-Myers Squibb, Wallingford, CT 06492, United States.

Kimberly A Widmann (KA)

Bristol-Myers Squibb, Wallingford, CT 06492, United States.

Valerie J Whiterock (VJ)

Bristol-Myers Squibb, Wallingford, CT 06492, United States.

Ping Chen (P)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Bristol Myers Squibb, Lawrenceville, NJ 08543, United States.

Cen Xu (C)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Amgen, Inc. Thousand Oaks, CA 91320, United States.

John J Herbst (JJ)

Bristol-Myers Squibb, Wallingford, CT 06492, United States.

Walter A Kostich (WA)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; National Multiple Sclerosis Society, New York, NY 10017, United States.

George Thalody (G)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Preformulation Solutions, LLC. North Ridgeville, OH 44039, United States.

John E Macor (JE)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Sanofi, Waltham, MA 02451, United States.

Gene M Dubowchik (GM)

Bristol-Myers Squibb, Wallingford, CT 06492, United States; Biohaven Pharmaceuticals Inc., New Haven, CT 06510, United States.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azépines › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Antagonistes du récepteur du peptide relié au gène de la calcitonine › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indazoles › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs du peptide relié au gène de la calcitonine › Azepino-indazoles as calcitonin gene-related...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Azepino-indazoles as calcitonin gene-related...