miR-1: A comprehensive review of its role in normal development and diverse disorders.
Development
Muscle
Tumor
miR-1
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
09
09
2020
revised:
13
10
2020
accepted:
14
10
2020
pubmed:
24
10
2020
medline:
26
2
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
MicroRNA-1 (miR-1) is a conserved miRNA with high expression in the muscle tissues. In humans, two discrete genes, MIRN1-1 and MIRN1-2 residing on a genomic region on 18q11.2 produce a single mature miRNA which has 21 nucleotides. miR-1 has a regulatory role on a number of genes including heat shock protein 60 (HSP60), Kruppel-like factor 4 (KLF4) and Heart And Neural Crest Derivatives Expressed 2 (HAND2). miR-1 has critical roles in the physiological processes in the smooth and skeletal muscles as well as other tissues, thus being involved in the pathogenesis of a wide range of disorders. Moreover, dysregulation of miR-1 has been noted in diverse types of cancers including gastric, colorectal, breast, prostate and lung cancer. In the current review, we provide the summary of the data regarding the role of this miRNA in the normal development and the pathogenic processes.
Identifiants
pubmed: 33096351
pii: S0753-3322(20)31095-7
doi: 10.1016/j.biopha.2020.110903
pii:
doi:
Substances chimiques
KLF4 protein, human
0
Kruppel-Like Factor 4
0
MIRN1 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110903Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.