Relational memory in the early stage of psychotic bipolar disorder.
Affective psychosis
Early psychosis
Eye movements
Hippocampus
Non-affective psychosis
associative memory
first episode
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
04
2020
accepted:
08
10
2020
pubmed:
24
10
2020
medline:
7
4
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
Relational memory is impaired in psychotic disorders. In non-affective psychotic disorders, relational memory deficits are present in the early stage of illness and become more pronounced in the chronic stage. Previous studies have demonstrated cognitive deficits in early-stage psychotic bipolar disorder, but it is unclear whether relational memory is impaired. We examined relational memory using a face-scene binding task in early-stage psychotic bipolar disorder patients (n = 33) and compared their performance with healthy control (n = 40) and early-stage non-affective psychosis participants (n = 40). During training, participants learned to associate faces with background scenes. During testing, participants viewed a scene overlaid by three faces and were asked to recall the matching face. Relational memory was assessed indirectly using eye movements and explicitly using forced-choice recognition. Preferential viewing of the matching face, as captured by overall proportion of viewing and viewing across time, was significantly lower in psychotic bipolar disorder than in the healthy control group. However, preferential viewing of the matching face in psychotic bipolar disorder was significantly better than in non-affective psychosis. These findings provide novel evidence that relational memory in patients with early-stage psychotic bipolar disorder is intermediate between healthy control and early-stage non-affective psychosis subjects.
Identifiants
pubmed: 33096436
pii: S0165-1781(20)33169-3
doi: 10.1016/j.psychres.2020.113508
pmc: PMC7809627
mid: NIHMS1639602
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113508Subventions
Organisme : NIMH NIH HHS
ID : R01 MH070560
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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