Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline.

Antimalarials / chemical synthesis Artemisinins / chemistry Fosfomycin / analogs & derivatives Molecular Structure Parasitic Sensitivity Tests Plasmodium falciparum / drug effects Quinolines / chemistry
antimalarial activity artemisinin chloroquine conjugates fosmidomycin hybrid

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
21 Oct 2020
Historique:
received: 26 09 2020
revised: 15 10 2020
accepted: 16 10 2020
entrez: 24 10 2020
pubmed: 25 10 2020
medline: 31 3 2021
Statut: epublish

Résumé

Malaria, despite many efforts, remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by

Identifiants

DOI: 10.3390/molecules25204858 PMID: 33096817 PMC: PMC7587979
pubmed: 33096817
pii: molecules25204858
doi: 10.3390/molecules25204858
pmc: PMC7587979
pii:
doi:

Substances chimiques

Antimalarials 0
Artemisinins 0
Quinolines 0
Fosfomycin 2N81MY12TE
fosmidomycin 5829E3D9I9
artemisinin 9RMU91N5K2
quinoline E66400VT9R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Despina Palla (D)

Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece.

Antonia I Antoniou (AI)

Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece.

Michel Baltas (M)

LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, CEDEX 9, 31062 Toulouse, France.
CNRS, LCC (Laboratoire de Chimie, de Coordination), Université de Tolouse, UPS, INPT, 205 Route de Narbonne, BP 44099, CEDEX 4 F-31077 Toulouse, France.

Christophe Menendez (C)

LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, CEDEX 9, 31062 Toulouse, France.
CNRS, LCC (Laboratoire de Chimie, de Coordination), Université de Tolouse, UPS, INPT, 205 Route de Narbonne, BP 44099, CEDEX 4 F-31077 Toulouse, France.

Philippe Grellier (P)

MCAM, UMR 7245, Muséum National d'Histoire Naturelle, CNRS, CP52, 63 rue Buffon, 75005 Paris, France.
ORCID: 0000-0003-4153-0465

Elisabeth Mouray (E)

MCAM, UMR 7245, Muséum National d'Histoire Naturelle, CNRS, CP52, 63 rue Buffon, 75005 Paris, France.

Constantinos M Athanassopoulos (CM)

Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece.
ORCID: 0000-0002-7549-1911

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Synthesis and Antiplasmodial Activity of Novel...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Synthesis and Antiplasmodial Activity of Novel...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Fosfomycine › Synthesis and Antiplasmodial Activity of Novel...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis and Antiplasmodial Activity of Novel...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité parasitaire › Synthesis and Antiplasmodial Activity of Novel...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Synthesis and Antiplasmodial Activity of Novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Synthesis and Antiplasmodial Activity of Novel...