Inefficient visual search strategies in the first-episode schizophrenia spectrum.
First-episode
Magnetoencephalography
N2pc
Schizophrenia spectrum
Selective attention
Visual search
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
08
01
2020
revised:
05
08
2020
accepted:
22
09
2020
pubmed:
25
10
2020
medline:
22
6
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
Knowledge is lacking regarding deficits in selective attention and their underlying biological mechanisms during early stages of schizophrenia. The present study examined the N2pc, a neurophysiological index of covert spatial attention, and its cortical sources at first psychotic episode in the schizophrenia spectrum (FESz). Neurophysiological responses measured simultaneously with magnetoencephalography (MEG) and electroencephalography (EEG) during pop-out and serial search tasks were compared between 32 FESz and 32 matched healthy controls (HC). Mean scalp-recorded N2pc was measured from a cluster of posterior-lateral EEG electrodes. Cortical source-resolved MEG activity contributing to the N2pc signal was derived for the intraparietal sulcus (IPS) and lateral occipital complex (LOC). Group differences in EEG N2pc varied by task demand. FESz exhibited reduced N2pc amplitude during pop-out (p < .01), but not serial search (p = .11). Furthermore, group differences in N2pc-related MEG cortical activity varied by task demand and cortical region. Compared to HC, FESz exhibited greater IPS during serial search (p < .01). Reductions in EEG N2pc amplitude indicate an impairment of visuo-spatial attention evident at an individual's first psychotic episode, specifically during conditions emphasizing bottom-up processing. Examination of its cortical sources with MEG revealed that, compared to HC, FESz engaged parietal structures to a greater extent during the serial search condition. This pattern suggests a less efficient, more resource intensive strategy employed by FESz in response to a minimal demand on attention. The greater reliance on this controlled attentional network may negatively impact real-world functions with much greater complexity and attentional demands.
Sections du résumé
BACKGROUND
Knowledge is lacking regarding deficits in selective attention and their underlying biological mechanisms during early stages of schizophrenia. The present study examined the N2pc, a neurophysiological index of covert spatial attention, and its cortical sources at first psychotic episode in the schizophrenia spectrum (FESz).
METHODS
Neurophysiological responses measured simultaneously with magnetoencephalography (MEG) and electroencephalography (EEG) during pop-out and serial search tasks were compared between 32 FESz and 32 matched healthy controls (HC). Mean scalp-recorded N2pc was measured from a cluster of posterior-lateral EEG electrodes. Cortical source-resolved MEG activity contributing to the N2pc signal was derived for the intraparietal sulcus (IPS) and lateral occipital complex (LOC).
RESULTS
Group differences in EEG N2pc varied by task demand. FESz exhibited reduced N2pc amplitude during pop-out (p < .01), but not serial search (p = .11). Furthermore, group differences in N2pc-related MEG cortical activity varied by task demand and cortical region. Compared to HC, FESz exhibited greater IPS during serial search (p < .01).
DISCUSSION
Reductions in EEG N2pc amplitude indicate an impairment of visuo-spatial attention evident at an individual's first psychotic episode, specifically during conditions emphasizing bottom-up processing. Examination of its cortical sources with MEG revealed that, compared to HC, FESz engaged parietal structures to a greater extent during the serial search condition. This pattern suggests a less efficient, more resource intensive strategy employed by FESz in response to a minimal demand on attention. The greater reliance on this controlled attentional network may negatively impact real-world functions with much greater complexity and attentional demands.
Identifiants
pubmed: 33097368
pii: S0920-9964(20)30473-4
doi: 10.1016/j.schres.2020.09.015
pmc: PMC7722051
mid: NIHMS1639609
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
126-132Subventions
Organisme : NIMH NIH HHS
ID : P50 MH103204
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH016804
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None of the authors reported any biomedical financial interests or potential conflicts of interest.
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