Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes.

Adult Body Weight Diabetes Mellitus, Type 2 / diagnostic imaging Female Gallium Radioisotopes Humans Kidney / metabolism Male Positron Emission Tomography Computed Tomography Radiometry Receptors, Glucagon / metabolism Tissue Distribution
PET glucagon metabolic disease obesity type 2 diabetes

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
01 06 2021
Historique:
received: 01 06 2020
accepted: 23 09 2020
pubmed: 25 10 2020
medline: 27 8 2021
entrez: 24 10 2020
Statut: ppublish

Résumé

Despite the importance of the glucagon receptor (GCGR) in disease and in pharmaceutical drug development, there is a lack of specific and sensitive biomarkers of its activation in humans. The PET radioligand

Identifiants

DOI: 10.2967/jnumed.118.213306 PMID: 33097629
pubmed: 33097629
pii: jnumed.118.213306
doi: 10.2967/jnumed.118.213306
doi:

Substances chimiques

Gallium Radioisotopes 0
Receptors, Glucagon 0
Gallium-68 98B30EPP5S

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

833-838

Informations de copyright

© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Olof Eriksson (O)

Antaros Medical AB, Uppsala, Sweden.
Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Irina Velikyan (I)

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Akademiska Sjukhuset, Uppsala, Sweden.

Torsten Haack (T)

R&D Research Platform, Integrated Drug Discovery, Sanofi, Frankfurt, Germany.

Martin Bossart (M)

R&D Research Platform, Integrated Drug Discovery, Sanofi, Frankfurt, Germany.

Iina Laitinen (I)

Global Imaging, Sanofi, Frankfurt, Germany.

Philip J Larsen (PJ)

R&D Research Platform, Integrated Drug Discovery, Sanofi, Frankfurt, Germany.

Jan Erik Berglund (JE)

Clinical Trial Consultants AB, Uppsala, Sweden; and.

Gunnar Antoni (G)

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Akademiska Sjukhuset, Uppsala, Sweden.

Lars Johansson (L)

Antaros Medical AB, Uppsala, Sweden.

Stefan Pierrou (S)

Antaros Medical AB, Uppsala, Sweden.

Joachim Tillner (J)

Translational Medicine, Sanofi, Frankfurt, Germany.

Michael Wagner (M)

R&D Research Platform, Integrated Drug Discovery, Sanofi, Frankfurt, Germany Michael.Wagner@sanofi.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Techniques d'investigation › Radiométrie › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone pancréatique › Récepteurs au glucagon › Imaging of the Glucagon Receptor in Subjects...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Imaging of the Glucagon Receptor in Subjects...