Triclosan exposure and in vitro fertilization treatment outcomes in women undergoing in vitro fertilization.
Clinical pregnancy
Early IVF outcomes
Environmental exposure
Implantation rate
Top quality embryo
Urinary triclosan concentrations
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
02
07
2020
accepted:
15
10
2020
pubmed:
25
10
2020
medline:
5
3
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
Triclosan (TCS) is a widespread environmental endocrine-disrupting chemical. Animal and in vitro studies suggested that triclosan may affect homesostasis of sex and thyroid hormones and impact on reproduction. Due to limited data derived from human epidemiological studies, this study was performed to examine the association between urinary concentration of triclosan and in vitro reproductive outcomes (methaphase II (MII) oocyte yield, top quality embryo, fertilization rate, implantation rate, and clinical pregnancy) among women from infertility clinic. The study participants were enrolled in an Infertility Center in Poland. A total of 450 women aged 25-45 (n = 674 IVF cycles) provided urine samples. The urinary concentrations of triclosan were evaluated using validated gas chromatography ion-tap mass spectrometry method. Clinical outcomes of IVF treatment were abstracted from patients electronic chart records. Triclosan was detected in urine of 82% of women with geometric mean 2.56 ± 6.13 ng/mL. Urinary concentrations of triclosan were associated with decrease implantation rate (p = 0.03). There were no association between other examined IVF outcomes: MII oocytes, embryo quality, fertilization rate, and exposure to triclosan. As this is one of the first study on this topic, studies among larger and more diverse population are needed to confirm the results.
Identifiants
pubmed: 33097990
doi: 10.1007/s11356-020-11287-w
pii: 10.1007/s11356-020-11287-w
pmc: PMC7921062
doi:
Substances chimiques
Triclosan
4NM5039Y5X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12993-12999Références
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