Modulation of the mitochondrial voltage-dependent anion channel (VDAC) by hydrogen peroxide and its recovery by curcumin.
Animals
Binding Sites
Brain
/ metabolism
Computer Simulation
Curcumin
/ chemistry
Cysteine
/ chemistry
Electrophysiology
Hydrogen Peroxide
/ chemistry
Ligands
Lipid Bilayers
/ chemistry
Lipids
/ chemistry
Mitochondria
/ metabolism
Molecular Conformation
Neurons
/ metabolism
Oxidative Stress
Oxygen
/ chemistry
Protein Isoforms
Rats
Rats, Wistar
Reactive Oxygen Species
Voltage-Dependent Anion Channel 1
/ chemistry
Voltage-Dependent Anion Channel 2
/ chemistry
Voltage-Dependent Anion Channels
/ metabolism
Antioxidant
Bilayer electrophysiology
Curcumin
Hydrogen peroxide
Single-channel recording
Voltage-dependent anion channel
Journal
European biophysics journal : EBJ
ISSN: 1432-1017
Titre abrégé: Eur Biophys J
Pays: Germany
ID NLM: 8409413
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
13
02
2020
accepted:
05
10
2020
revised:
25
09
2020
pubmed:
25
10
2020
medline:
3
8
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
The Voltage-Dependent Anion Channel (VDAC) plays a vital role in mitochondria-mediated transport of ions and metabolites. It is well established that mitochondria are a site for production of hydrogen peroxide (H
Identifiants
pubmed: 33098437
doi: 10.1007/s00249-020-01469-2
pii: 10.1007/s00249-020-01469-2
doi:
Substances chimiques
Ligands
0
Lipid Bilayers
0
Lipids
0
Protein Isoforms
0
Reactive Oxygen Species
0
Vdac1 protein, rat
0
Vdac2 protein, rat
0
Voltage-Dependent Anion Channel 2
0
Voltage-Dependent Anion Channels
0
Hydrogen Peroxide
BBX060AN9V
Voltage-Dependent Anion Channel 1
EC 1.6.-
Curcumin
IT942ZTH98
Cysteine
K848JZ4886
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM