Characteristics of Early Internal Laryngeal Muscle Atrophy After Recurrent Laryngeal Nerve Injuries in Rats.
Animals
Biomarkers
/ metabolism
Disease Models, Animal
Laryngeal Muscles
/ metabolism
Muscle Proteins
/ metabolism
Muscular Atrophy
/ etiology
NF-kappa B
/ metabolism
Rats
Rats, Sprague-Dawley
Recurrent Laryngeal Nerve Injuries
/ complications
Tripartite Motif Proteins
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
Recurrent laryngeal nerve injury
internal laryngeal muscle
muscle RING-finger protein-1
muscle atrophy
nuclear factor-kappa B
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
01
06
2020
revised:
09
10
2020
accepted:
15
10
2020
pubmed:
25
10
2020
medline:
10
4
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
The present study investigated the characteristics of early internal laryngeal muscle atrophy in recurrent laryngeal nerve injury (RLNI) rats. To observe the characteristics of early internal laryngeal muscle atrophy post RLNI. Rats were divided into three groups: sham-operated control group (n = 20), recurrent laryngeal nerve transverse injury group (RLNTI, n = 50), and recurrent laryngeal nerve blunt contusion group (RLNBC, n = 50). Five weeks after RLNI, certain rats were sacrificed weekly, and their laryngeal tissues were harvested. The atrophic features of internal laryngeal muscles were detected using hematoxylin and eosin. NF-κB and MuRF-1 levels were tested using IHC. The atrophic degree and fibrosis of thyroarytenoid, posterior cricoarytenoid, and lateral cricoarytenoid muscles were related to the type of RLNI. The average myofiber cross-sectional areas increased before an obvious decrease in the RLNTI and RLNBC groups. Muscle recovery occurred in the RLNBC group starting 4 weeks after RLNI, but only a weak trend was observed in the RLNTI group in the 5th week. During the muscle atrophy process, MuRF-1 and NF-κB were upregulated early and were maintained at a high level, which showed a trend similar to muscle atrophy. However, NF-κB expression was opposite to MuRF-1 expression and muscle atrophy when the muscles recovered. The atrophy degree of internal laryngeal muscles was associated with the type of RLNI. The NF-κB/MuRF-1 signaling pathway was involved in internal laryngeal muscle atrophy after RLNI, which is different from skeletal muscle after denervation. NA Laryngoscope, 131:E1256-E1264, 2021.
Substances chimiques
Biomarkers
0
Muscle Proteins
0
NF-kappa B
0
Tripartite Motif Proteins
0
Trim63 protein, rat
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1256-E1264Informations de copyright
© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).
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