Cyanide Bridged Platinum-Iron Complexes as Cisplatin Prodrug Systems: Design and Computational Study.


Journal

Chemphyschem : a European journal of chemical physics and physical chemistry
ISSN: 1439-7641
Titre abrégé: Chemphyschem
Pays: Germany
ID NLM: 100954211

Informations de publication

Date de publication:
07 01 2021
Historique:
received: 30 08 2020
revised: 13 10 2020
pubmed: 25 10 2020
medline: 16 6 2021
entrez: 24 10 2020
Statut: ppublish

Résumé

The potential role of cyanide-bridged platinum-iron complexes as an anti-cancer Pt(IV) prodrug is studied. We present design principles of a dual-function prodrug that can upon reduction dissociate and release concurrently six cisplatin units and a ferricyanide anion per prodrug unit. The prodrug molecule is a unique complex of hepta metal centers consisting of a ferricyanide core with six Pt(IV) centers each bonded to the Fe(III) core through a cyano ligand. The functionality of the prodrug is addressed through density functional theory (DFT) calculations.

Identifiants

pubmed: 33098742
doi: 10.1002/cphc.202000748
doi:

Substances chimiques

Antineoplastic Agents 0
Coordination Complexes 0
Cyanides 0
Ligands 0
Prodrugs 0
Platinum 49DFR088MY
Iron E1UOL152H7
Cisplatin Q20Q21Q62J

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

106-111

Subventions

Organisme : Department of Energy, basic energy sciences
ID : DE-SC0016501
Pays : International
Organisme : Kent State University for partial support and for generous resource allocation on the Ohio Supercomputer Center
ID : PAA-0213
Pays : International

Informations de copyright

© 2020 Wiley-VCH GmbH.

Références

B. Rosenberg, L. Van Camp, T. Krigas, Nature 1965, 205, 698-699.
National institutes of health. clinical trials database. accessed: 2015. http://www.clinicaltrials.gov.
H. P. Varbanov, M. A. Jakupec, A. Roller, F. Jensen, M. Galanski, B. K. Keppler, J. Med. Chem. 2013, 56, 330-344.
T. C. Johnstone, K. Suntharalingam, S. J. Lippard, Chem. Rev. 2016, 116, 3436-3486.
R. Zhang, X.-Q. Song, R.-P. Liu, Z.-Y. Ma, J.-Y. Xu, J. Med. Chem. 2019, 62, 4543-4554.
V. P. Ting, M. Schmidtmann, C. C. Wilson, M. T. Weller, Angew. Chem., Int. Ed. 2010, 122, 9598-9601.
N. Tasinato, C. Puzzarini, V. Barone, Angew. Chem., Int. Ed. 2017, 56, 13838-13841.
D. Veclani, A. Melchior, M. Tolazzi, J. P. Cerón-Carrasco, J. Am. Chem. Soc. 2018, 140, 14024-14027.
J. J. Roberts, J. M. Pascoe, Nature 1972, 235, 282-284.
E. R. Jamieson, S. J. Lippard, Chem. Rev. 1999, 99, 2467.
P. J. Loehrer, L. H. Einhorn, Ann. Intern. Med. 1984, 100, 704-713.
E. Wexselblatt, D. Gibson, J. Inorg. Biochem. 2012, 117, 220-229.
D. Miodragovic, A. Merlino, E. P. Swindell, A. Bogachkov, R. W. Ahn, S. Abuhadba, G. Ferraro, T. Marzo, A. P. Mazar, L. Messori, T. V. O'Halloran, J. Am. Chem. Soc. 2019, 141, 6453-6457.
G. R. Gibbons, S. Wyrick, S. G. Chaney, Cancer Res. 1989, 49, 1402-1407.
M. D. Hall, H. R. Mellor, R. Callaghan, T. W. Hambley, J. Med. Chem. 2007, 50, 3403-3411.
P. Bouchal, J. Jarkovsky, K. Hrazdilova, M. Dvorakova, I. Struharova, L. Hernychova, J. Damborsky, P. Sova, B. Vojtesek, Proteome science 2011, 9, 68.
S. Dhar, F. X. Gu, R. Langer, O. C. Farokhzad, S. J. Lippard, Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 17356-17361.
M. C. McCormick, K. Keijzer, A. Polavarapu, F. A. Schultz, M.-H. Baik, J. Am. Chem. Soc. 2014, 136, 8992-9000.
L. Fang, X. Qin, J. Zhao, S. Gou, Inorg. Chem. 2019, 58, 2191-2200.
M. V. Babak, Y. Zhi, B. Czarny, T. B. Toh, L. Hooi, E. Kai-Hua Chow, W. H. Ang, D. Gibson, G. Pastorin, Angew. Chem., Int. Ed. 2019, 58, 8109-8114.
Y. Shi, J. Goodisman, J. C. Dabrowiak, Inorg. Chem. 2013, 52, 418-9426.
J. Karges, T. Yempala, M. Tharaud, D. Gibson, G. Gasser, Angew. Chem., Int. Ed. 2020, 59, 7069-7075.
Z. Zheng, A. K. Manna, H. P. Hendrickson, M. Hammer, C. Song, E. Geva, B. D. Dunietz, J. Am. Chem. Soc. 2014, 136, 16954-16957.
B. W. Pfennig, A. B. Bocarsly, J. Phys. Chem. 1992, 96, 226-233.
D. F. Watson, H. S. Tan, E. Schreiber, C. J. Mordas, A. B. Bocarsly, J. Phys. Chem. A 2004, 108, 3261-3267.
M. S. Lynch, M. Cheng, B. E. Van Kuiken, M Khalil, J. Chem. Phys. 2012, 136, 241101.
Y. Zhao, D. G. Truhlar, Acc. Chem. Res. 2008, 41, 157-167.
C. Lee, W. Yang, R. G. Parr, Phys. Rev. B 1988, 37, 85-789.
J.-D. Chai, M. Head-Gordon, Phys. Chem. Chem. Phys. 2008, 10, 6615.
S. Grimme, WIREs Comput. Mol. Sci. 2011, 1, 211-228.
L. A. Burns, Á. Vázquez Mayagoitia, B. G. Sumpter, C. D. Sherrill, J. Chem. Phys. 2011, 134, 084107.
N. Tasinato, S. Grimme, Phys. Chem. Chem. Phys. 2015, 17, 5659-5669.
S. Grimme, J. Antony, S. Ehrlich, H. Krieg, J. Chem. Phys 2010, 132, 154104.
N. Rega, M. Cossi, V. Barone, J. Am. Chem. Soc. 1997, 119, 12962-12967.
J. Tomasi, B. Mennucci, R. Cammi, Chem. Rev. 2005, 105, 2999-3094.
A. W. Lange, J. M. Herbert, J. Chem. Phys. 2010, 133, 244111.
A. W. Lange, J. M. Herbert, Chem. Phys. Lett. 2011, 509, 77-78.
Y. Shao, Z. Gan, E. Epifanovsky, A. T. B. Gilbert, M. Wormit, J. Kussmann, A. W. Lange, A. Behn, J. Deng, X. Feng, Mol. Phys. 2015, 113, 184-215.
S. Tran, P.-J. DeGiovanni, B. Piel, P. Rai, Clin Trans Med 2017, 6, 44.
M. Shatruk, C. Avendano, K. R Dunbar, Prog. Inorg. Chem. 2009, 56, 155-334.
F. Yu, Y.-m. Zhang, A.-h. Li, Y.-h. Guo, B. Li, J. Tao, Inorg. Chem. Commun. 2014, 48, 5-7.
C. J. Mordas, B. W. Pfennig, A. B. Bocarsly, E. Schreiber. Ultrafast pump-probe and resonance raman spectroscopic study of excited state electronic coupling in two related hexanuclear charge transfer compounds. In International Conference on Ultrafast Phenomena, page WD21. Optical Society of America, 2002.
B. W. Pfennig, C. J. Mordas, A. McCloskey, J. V. Lockard, P. M. Salmon, J. L. Cohen, D. F. Watson, A. B. Bocarsly, Inorg. Chem. 2002, 41, 4389-4395.
P. A. Chase, R. J. M. Klein Gebbink, G. van Koten, J. Organometal. Chem. 2004, 689, 4016-4054.
A. S. Abd-El-Aziz, E. A. Strohm, Polymer 2012, 53, 4879-4921.
U. J. Chigbo, A. E. Ugochukwu, F. Dingwoke, Univers. J. Pharm. Res. 2017, 2, 34.
H.-Y. Lian, M. Hu, C.-H. Liu, Y. Yamauchi, K. C.-W. Wu, ChemComm 2012, 48, 5151-5153.
D. H. Manz, N. L. Blanchette, B. T. Paul, F. M. Torti, S. V. Torti, Ann. N. Y. Acad. Sci. 2016, 1368, 149.
Ohio supercomputer center. http://osc.edu/ark:/19495/f5 s1ph73.

Auteurs

Ariela W Kaspi-Kaneti (AW)

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.

Srijana Bhandari (S)

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.

Alexander Schubert (A)

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Present address: Institute of Physical Chemistry, Friedrich Schiller University Jena, 07743, Jena, Germany.

Songping D Huang (SD)

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.

Barry D Dunietz (BD)

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs
Humans Male Female Health Knowledge, Attitudes, Practice Middle Aged
Alzheimer Disease Humans Regression Analysis Quantitative Structure-Activity Relationship Drug Design
Humans Female Alopecia Breast Neoplasms Middle Aged

Classifications MeSH