FairEmbo Concept for Arterial Embolizations: In Vivo Feasibility and Safety Study with Suture-Based Microparticles Compared with Microspheres.

Angiography, Digital Subtraction Animals Arteries / diagnostic imaging Disease Models, Animal Embolization, Therapeutic / methods Feasibility Studies Microspheres Renal Artery Suture Techniques / instrumentation Sutures Swine Tomography, X-Ray Computed Vascular Surgical Procedures / methods
Distal embolization Embozene® Emerging countries FairEmbo Suture-based microparticles

Journal

Cardiovascular and interventional radiology
ISSN: 1432-086X
Titre abrégé: Cardiovasc Intervent Radiol
Pays: United States
ID NLM: 8003538

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 25 07 2020
accepted: 03 10 2020
pubmed: 26 10 2020
medline: 8 6 2021
entrez: 25 10 2020
Statut: ppublish

Résumé

Microspheres are effective embolic agents, especially for the management of bleeding and oncologic lesions. The first FairEmbo study reported the effectiveness of embolization using suture fragments. The effectiveness and safety of arterial embolization with suture-based microparticles (SBM) were assessed in a swine model. In this ethical-approved animal study, a polar artery in each kidney was embolized in four swine: one side with hand-cut non-absorbable SBM (Flexocrin 2®) and the contralateral side with Embozene® 900 for comparison. Swine were followed for 3 months (M3) to evaluate the effectiveness and the safety of SBM. Follow-up protocol included clinical monitoring, computed tomography (CT) control and digital subtraction angiography (DSA), followed by histological analyses. The SBM confection parameters were evaluated by automatic microscopic sizer. RStudio software and Mann-Whitney test (significance at P < 0.05) were used for statistics. The average size of SBM was 1002 μm (SD = 258). All targets were effectively embolized by SBM with an angiogram defect estimated at 45.6% (95% CI [35.9-55.2]), compared to 40.5% (95% CI [30.6-55.5]) for Embozene® group (P = 0.342). The average duration of SBM embolization procedure was significantly increased compared to Embozene® embolization (1202 s versus 222 s, P = 0.029). There were no statistical differences in M3 DSA and CT for SBM and Embozene®, with persistence of partial arterial occlusion and atrophic embolized area. No postoperative complications were observed on clinical and CT controls. This experimental study suggests that embolization with SBM is feasible, safe and effective in short- and medium-term follow-up as compared to microspheres.

Identifiants

DOI: 10.1007/s00270-020-02678-0 PMID: 33099701
pubmed: 33099701
doi: 10.1007/s00270-020-02678-0
pii: 10.1007/s00270-020-02678-0
doi:

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

625-632

Commentaires et corrections

Type : CommentIn

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Auteurs

Mathieu Di Bisceglie (M)

Interventional Radiololy Section, Department of Medical Imaging, University Hospital Timone, APHM, Marseille, France. Mathieu.di-bisceglie@ap-hm.fr.
LiiE, Aix Marseille University, Marseille, France. Mathieu.di-bisceglie@ap-hm.fr.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France. Mathieu.di-bisceglie@ap-hm.fr.
ORCID: 0000-0002-9530-2006

Jean-Francois Hak (JF)

Interventional Radiololy Section, Department of Medical Imaging, University Hospital Timone, APHM, Marseille, France.
LiiE, Aix Marseille University, Marseille, France.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.

Abdoulaye Dione Diop (AD)

Diagnostic and Medical Imaging Center, Fann National University Hospital Center, 5035, Dakar, Senegal.

Gloria Salazar (G)

Division of Interventional Radiology, Massachusetts General Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Pauline Brige (P)

LiiE, Aix Marseille University, Marseille, France.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.

Julien Panneau (J)

Interventional Radiololy Section, Department of Medical Imaging, University Hospital Timone, APHM, Marseille, France.
LiiE, Aix Marseille University, Marseille, France.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.

Farouk Tradi (F)

Interventional Radiololy Section, Department of Medical Imaging, University Hospital Timone, APHM, Marseille, France.
LiiE, Aix Marseille University, Marseille, France.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.
Department of Radiology, University Hospital Center of Montreal, Montreal, Canada.

Paul Habert (P)

Interventional Radiololy Section, Department of Medical Imaging, University Hospital Timone, APHM, Marseille, France.
LiiE, Aix Marseille University, Marseille, France.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.

Jacques-Yves Campion (JY)

CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.

Abdoulaye Ndoye Diop (AN)

UFR 2S, Gaston Berger University, BP234, Saint Louis, Senegal.

Gilles Soulez (G)

Department of Radiology, University Hospital Center of Montreal, Montreal, Canada.

Benjamin Guillet (B)

CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.
INSERM1263, INRA 1260, C2VN, Aix Marseille University, Marseille, France.
Department of Radiopharmacy, APHM, Marseille, France.

Vincent Vidal (V)

Interventional Radiololy Section, Department of Medical Imaging, University Hospital Timone, APHM, Marseille, France.
LiiE, Aix Marseille University, Marseille, France.
CERIMED, Aix Marseille University, 27 Bd Jean Moulin 13005, Marseille, France.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Angiographie › Angiographie de soustraction digitale › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Eucaryotes › Animaux › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Thérapeutique › Occlusion thérapeutique › Embolisation thérapeutique › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études de faisabilité › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Équipement et fournitures › Microsphères › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artère rénale › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Procédures de chirurgie opératoire › Techniques de fermeture des plaies › Techniques de suture › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Équipement et fournitures › Équipement chirurgical › Matériels de fixation chirurgicale › Matériaux de suture › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › FairEmbo Concept for Arterial Embolizations:...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie cardiovasculaire › Procédures de chirurgie vasculaire › FairEmbo Concept for Arterial Embolizations:...