Wnt/PCP signalling cascade disruption by JNK inhibition as a potential mechanism underlying the teratogenic effects of potato glycoalkaloids.
Animals
Cell Movement
/ drug effects
Cell Polarity
/ drug effects
Epithelial Cells
/ drug effects
Humans
JNK Mitogen-Activated Protein Kinases
/ antagonists & inhibitors
Models, Biological
Neural Tube Defects
/ chemically induced
Solanine
/ toxicity
Solanum tuberosum
/ chemistry
Teratogenesis
/ drug effects
Wnt Signaling Pathway
/ drug effects
JNK
Neural tube defects
Potato glycoalkaloids
Teratology
Wnt/pcp pathway
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
13
08
2020
accepted:
13
10
2020
pubmed:
26
10
2020
medline:
25
5
2021
entrez:
25
10
2020
Statut:
ppublish
Résumé
It is hypothesised that the inhibition of the non-canonical Wnt/PCP intracellular signalling cascade by potato glycoalkaloids, [Formula: see text]-solanine and [Formula: see text]-chaconine, results in an increased risk of neural tube defects (NTDs). One very prominent intracellular signalling pathway with substantial implications in the development and closure of the neural tube is the Wnt/PCP pathway. Experimental inhibition of this results in NTDs. A vital element of this signalling cascade is JNK, which controls the transcription of DNA, which controls cell polarity and directional cell migration. JNK inhibition also results in NTDs experimentally. Through their use in cancer research, [Formula: see text]-solanine and [Formula: see text]-chaconine were found to inhibit metastasis by inhibiting JNK, among other intracellular signalling molecules. Thus, this shows that potato glycoalkaloids increase the likelihood of causing NTDs by inhibiting the proper functioning of JNK in the Wnt/PCP pathway, resulting in defective neural tube closure.
Identifiants
pubmed: 33099761
doi: 10.1007/s11033-020-05921-6
pii: 10.1007/s11033-020-05921-6
doi:
Substances chimiques
Solanine
20562-02-1
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9235-9238Références
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