Clinical features associated with a doctor-diagnosis of bronchiectasis in the Severe Asthma Network in Italy (SANI) registry.

Asthma / diagnosis Bronchiectasis / diagnosis Humans Italy / epidemiology Quality of Life Registries
Severe asthma bronchiectasis phenotypes real-life registry

Journal

Expert review of respiratory medicine
ISSN: 1747-6356
Titre abrégé: Expert Rev Respir Med
Pays: England
ID NLM: 101278196

Informations de publication

Date de publication:
03 2021
Historique:
pubmed: 27 10 2020
medline: 25 2 2023
entrez: 26 10 2020
Statut: ppublish

Résumé

Several severe asthma comorbidities have been identified: an emerging one is bronchiectasis. We evaluated the frequency of bronchiectasis on severe asthma in a real-life setting, through the 'Severe Asthma Network Italy' (SANI) registry. SANI registry encompasses demographic, clinical, functional and inflammatory data of Italian severe asthmatics. Data obtained by the enrolled patients were analyzed, focusing the attention on those patients with concomitant clinically relevant bronchiectasis. About 15.5% patients have bronchiectasis. Bronchiectasis diagnosis was associated with a higher prevalence of chronic rhinosinusitis with nasal polyps (54.6% vs. 38%, p = 0.001) and higher serum IgE levels (673.4 vs. 412.1 kUI/L, p = 0.013). Patients with bronchiectasis had worse asthma control (ACT: 16.7 vs 18.2, p = 0.013), worse quality of life (AQLQ: 4.08 vs. 4.60, p = 0.02) and lower lung function (FEV severe asthma associated with bronchiectasis represents a particularly severe asthma variant, possibly driven by an eosinophilic endotype. We, therefore, suggest that bronchiectasis should necessarily be assessed in severe asthmatic patients.

Sections du résumé

BACKGROUND
Several severe asthma comorbidities have been identified: an emerging one is bronchiectasis. We evaluated the frequency of bronchiectasis on severe asthma in a real-life setting, through the 'Severe Asthma Network Italy' (SANI) registry.
METHODS
SANI registry encompasses demographic, clinical, functional and inflammatory data of Italian severe asthmatics. Data obtained by the enrolled patients were analyzed, focusing the attention on those patients with concomitant clinically relevant bronchiectasis.
RESULTS
About 15.5% patients have bronchiectasis. Bronchiectasis diagnosis was associated with a higher prevalence of chronic rhinosinusitis with nasal polyps (54.6% vs. 38%, p = 0.001) and higher serum IgE levels (673.4 vs. 412.1 kUI/L, p = 0.013). Patients with bronchiectasis had worse asthma control (ACT: 16.7 vs 18.2, p = 0.013), worse quality of life (AQLQ: 4.08 vs. 4.60, p = 0.02) and lower lung function (FEV
CONCLUSION
severe asthma associated with bronchiectasis represents a particularly severe asthma variant, possibly driven by an eosinophilic endotype. We, therefore, suggest that bronchiectasis should necessarily be assessed in severe asthmatic patients.

Identifiants

DOI: 10.1080/17476348.2021.1840983 PMID: 33100041
pubmed: 33100041
doi: 10.1080/17476348.2021.1840983
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

419-424

Auteurs

Giacomo Malipiero (G)

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.

Giovanni Paoletti (G)

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Francesco Blasi (F)

Internal Medicine Department, Respiratory Unit and Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milano, Italy.
ORCID: 0000-0002-2285-9970

Pierluigi Paggiaro (P)

Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.

Gianenrico Senna (G)

Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.

Manuela Latorre (M)

Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.

Marco Caminati (M)

Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.
ORCID: 0000-0001-7383-1487

Giovanna Elisiana Carpagnano (GE)

Respiratory Medicine Section, Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.

Nunzio Crimi (N)

Respiratory Medicine Unit, A.O.U. "Policlinico-Vittorio Emanuele", Catania, Italy.
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
ORCID: 0000-0002-8591-4535

Antonio Spanevello (A)

Faculty of Medicine and Surgery, University of Insubria, Varese, Italy.
Division of Pulmonary Rehabilitation, Maugeri Care and Research Institute, IRCCS, Tradate, Italy 3.

Stefano Aliberti (S)

Internal Medicine Department, Respiratory Unit and Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milano, Italy.

Giorgio Walter Canonica (GW)

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
ORCID: 0000-0001-8467-2557

Enrico Heffler (E)

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
ORCID: 0000-0002-0492-5663

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Clinical features associated with a...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies des bronches › Dilatation des bronches › Clinical features associated with a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical features associated with a...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Clinical features associated with a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Clinical features associated with a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Clinical features associated with a...