Study of Prothrombotic Changes in Metabolic Syndrome.
Activated partial thromboplastin time (APTT)
Coagulation
Factor VIII
Fibrinogen
Metabolic syndrome
Plasminogen activator inhibitor-1 (PAI-1)
Prothrombin time (PT)
Journal
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
ISSN: 0971-4502
Titre abrégé: Indian J Hematol Blood Transfus
Pays: India
ID NLM: 9425818
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
25
12
2019
accepted:
12
05
2020
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
ppublish
Résumé
The metabolic syndrome is a complex disorder of various metabolic risk factors in a single individual having central obesity and commonly associated with diabetes and cardiovascular diseases. The aim of our study was to study the relationship between coagulation abnormalities and metabolic syndrome. We performed a prospective cross-sectional study in a tertiary care hospital. A total of fifty cases of metabolic syndrome and fifty age & sex matched controls were selected. These two groups were investigated for Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen levels, Plasminogen Activator Inhibitor 1(PAI1) levels and Factor VIII levels. In cases with metabolic syndrome, significantly increased levels of Fibrinogen, Factor VIII and Plasminogen Activator Inhibitor1 (PAI1) were observed. PT & APTT were shorter in cases with metabolic syndrome. The coagulation parameters studied, correlated significantly with the components of metabolic syndrome. Metabolic syndrome is a hypercoagulable state and further studies are required for further evaluation of the consequences of this hypercoagulable state. There is a need for clinical trials evaluating prophylactic anticoagulation for prevention of venous thrombosis in patients with metabolic syndrome.
Identifiants
pubmed: 33100712
doi: 10.1007/s12288-020-01291-y
pii: 1291
pmc: PMC7572991
doi:
Types de publication
Journal Article
Langues
eng
Pagination
695-699Informations de copyright
© Indian Society of Hematology and Blood Transfusion 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that there is no conflict of interests.
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