Cardiovascular disease risk is associated with middle cerebral artery blood flow velocity in older adults.
aging
brain health
ultrasound imaging
Journal
Cardiopulmonary physical therapy journal
ISSN: 1541-7891
Titre abrégé: Cardiopulm Phys Ther J
Pays: United States
ID NLM: 101155626
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate the We recruited individuals who were cognitively normal older adults. CVD risk was assessed by the Pooled Cohort atherosclerotic cardiovascular disease (ASCVD) risk score. Transcranial Doppler ultrasound measured middle cerebral artery at rest and during a bout of moderate intensity exercise. We quantified white matter lesions from MRI and cognitive function outcomes included executive function, language, processing speed, and attention. Seventy-two participants 70.1 ± 4.7 years of age completed the study protocol. ASCVD risk score was significantly associated with resting and exercise MCAv (p<0.01) but not associated with white matter lesions (p>0.468). We observed a significant association between resting and exercise MCAv and language processing (p=0.010) but not other cognitive domains. In cognitively normal older adults, higher ASCVD risk score was associated with blunted resting and exercise MCAv and with lower language processing performance. These results highlight the need for CVD risk management to maintain optimal brain health.
Identifiants
pubmed: 33100924
doi: 10.1097/cpt.0000000000000110
pmc: PMC7580865
mid: NIHMS1519633
doi:
Types de publication
Journal Article
Langues
eng
Pagination
38-46Subventions
Organisme : NIA NIH HHS
ID : R01 AG043962
Pays : United States
Organisme : NICHD NIH HHS
ID : K01 HD067318
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD057850
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072973
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000001
Pays : United States
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