Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL.
CADASIL
GLUT2
GLUT4
VSMCs
stroke
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
04
2020
accepted:
10
08
2020
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
Typical cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the human NOTCH3 gene. Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy is characterized by subcortical ischemic strokes due to severe arteriopathy and fibrotic thickening of small vessels. Blood regulating vascular smooth muscle cells (VSMCs) appear as the key target in CADASIL but the pathogenic mechanisms remain unclear. With the hypothesis that brain glucose metabolism is disrupted in VSMCs in CADASIL, we investigated post-mortem tissues and VSMCs derived from CADASIL patients to explore gene expression and protein immunoreactivity of glucose transporters (GLUTs), particularly GLUT4 and GLUT2 using quantitative RT-PCR and immunohistochemical techniques.
Identifiants
pubmed: 33101365
doi: 10.3389/fgene.2020.01022
pmc: PMC7522350
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1022Subventions
Organisme : Medical Research Council
ID : G0400074
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0502157
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0900652
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100540
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Panahi, Rodriguez, Fereshtehnejad, Arafa, Bogdanovic, Winblad, Cedazo-Minguez, Rinne, Darreh-Shori, Hase, Kalaria, Viitanen and Behbahani.
Références
Int J Cardiol. 2017 Mar 1;230:70-75
pubmed: 28034463
Physiol Rep. 2015 Feb 12;3(2):
pubmed: 25677552
Physiol Rev. 2003 Jan;83(1):183-252
pubmed: 12506130
Neurology. 2012 Jan 17;78(3):167-74
pubmed: 22170884
BMC Med. 2017 Feb 24;15(1):41
pubmed: 28231783
Oncotarget. 2016 Jul 12;7(28):43220-43238
pubmed: 27281612
Am J Physiol. 1994 Nov;267(5 Pt 2):F816-24
pubmed: 7977785
Am J Hypertens. 1994 Apr;7(4 Pt 1):357-62
pubmed: 8031552
Brain. 2011 Dec;134(Pt 12):3716-27
pubmed: 22171356
Brain Pathol. 2014 Sep;24(5):525-44
pubmed: 25323668
Am J Physiol Cell Physiol. 2013 Mar;304(6):C574-89
pubmed: 23302780
Jpn J Physiol. 2004 Aug;54(4):357-63
pubmed: 15631691
Biomaterials. 2017 Mar;119:23-32
pubmed: 27988406
Neurobiol Aging. 2015 Aug;36(8):2443.e1-7
pubmed: 26002683
J Cereb Blood Flow Metab. 2012 Dec;32(12):2171-80
pubmed: 22948298
Brain Behav. 2017 Feb 22;7(3):e00624
pubmed: 28293466
Curr Pain Headache Rep. 2017 Apr;21(4):21
pubmed: 28281108
Nature. 1996 Oct 24;383(6602):707-10
pubmed: 8878478
Am J Kidney Dis. 1999 Jul;34(1):189-202
pubmed: 10401038
Circulation. 1995 Sep 15;92(6):1597-603
pubmed: 7664446
Neuropathol Appl Neurobiol. 2015 Jun;41(4):557-70
pubmed: 25303037
Methods Mol Biol. 2012;849:261-74
pubmed: 22528096
Stroke. 2009 Jun;40(6):2004-11
pubmed: 19359623
J Nucl Med. 2003 Jun;44(6):862-9
pubmed: 12791811
J Diabetes Investig. 2017 Mar;8(2):134-148
pubmed: 27239779
Horm Metab Res. 1996 Jun;28(6):271-5
pubmed: 8811327
J Hematol Oncol. 2017 Jan 7;10(1):11
pubmed: 28061796
Mol Med. 2007 May-Jun;13(5-6):305-14
pubmed: 17622327
Kidney Int. 1992 Nov;42(5):1086-92
pubmed: 1453596
J Hypertens. 2001 Sep;19(9):1581-7
pubmed: 11564977
Lancet Neurol. 2007 Jul;6(7):611-9
pubmed: 17582361
Neuropathol Appl Neurobiol. 2014 Aug;40(5):591-602
pubmed: 23844775
J Cell Biol. 1974 Mar;60(3):673-84
pubmed: 4363161
Neurochem Int. 2010 Nov;57(6):668-75
pubmed: 20705111
Hum Mol Genet. 2010 Jan 1;19(1):79-89
pubmed: 19825845
J Biol Chem. 2002 Jun 14;277(24):21723-9
pubmed: 11925448
J Nucl Med. 1994 Jan;35(1):1-6
pubmed: 8271029
J Cereb Blood Flow Metab. 1991 Mar;11(2):323-30
pubmed: 1997504
Alzheimers Dement. 2018 Mar;14(3):280-292
pubmed: 29055812
Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1596-602
pubmed: 15890973
Brain Pathol. 2013 Sep;23(5):547-57
pubmed: 23387519
Arch Biochem Biophys. 1993 May;302(2):490-8
pubmed: 8489251
Stroke. 2014 Sep;45(9):2689-94
pubmed: 25034716
Acta Neuropathol Commun. 2019 Feb 7;7(1):16
pubmed: 30732655
Handb Clin Neurol. 2018;148:733-743
pubmed: 29478611
NMR Biomed. 2003 Dec;16(8):494-502
pubmed: 14696007
Stroke. 2004 May;35(5):1063-7
pubmed: 15017012
J Mol Med (Berl). 2017 Feb;95(2):181-192
pubmed: 27631639
Stroke. 2001 Aug;32(8):1767-74
pubmed: 11486103
Stroke. 2007 Oct;38(10):2692-7
pubmed: 17761910
J Stroke. 2015 Jan;17(1):7-16
pubmed: 25692103
J Cell Mol Med. 2018 Jun;22(6):3016-3024
pubmed: 29536621
Exp Cell Res. 2013 Feb 1;319(3):134-43
pubmed: 23036509
J Cell Physiol. 2009 May;219(2):494-502
pubmed: 19180562
Obes Rev. 2010 May;11(5):380-8
pubmed: 19694967
Acta Neuropathol Commun. 2019 Nov 21;7(1):187
pubmed: 31753008