COVID-19 and diabetes mellitus: Unraveling the hypotheses that worsen the prognosis (Review).

COVID-19 SARS-CoV-2 infection angiotensin converting enzyme 2 diabetes mellitus hypotheses skin complications

Journal

Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 10 07 2020
accepted: 11 08 2020
entrez: 26 10 2020
pubmed: 27 10 2020
medline: 27 10 2020
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the caused disease - coronavirus disease 2019 (COVID-19), has affected so far >6,000,000 people worldwide, with variable grades of severity, and has already inflicted >350,000 deaths. SARS-CoV-2 infection seems severely affected by background diseases such as diabetes mellitus and its related complications, that seem to be favoring the most severe manifestations of SARS-CoV-2 and, therefore, require special attention in clinical care units. The present literature review focus on addressing several hypotheses explaining why diabetic patients could develop multi-organ failure in severe acute respiratory syndrome coronavirus (SARS-CoV) infections. Undoubtedly, as diabetes related complications are present it is expected to emphasize the severity of the COVID-19. Dermatological complications can occur and worsen in diabetic patients, and diseases such as acanthosis nigricans and psoriasis are prone to more severe manifestations of COVID-19. Approaches to treat SARS-CoV-2 infected patients, based on different solutions i.e. plasma therapy, use of antiviral compounds, development of vaccines or new therapeutic agents are ongoing.

Identifiants

pubmed: 33101484
doi: 10.3892/etm.2020.9324
pii: ETM-0-0-09324
pmc: PMC7579812
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

194

Informations de copyright

Copyright © 2020, Spandidos Publications.

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Auteurs

Radu Albulescu (R)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
National Institute for Chemical-Pharmaceutical R&D, 031299 Bucharest, Romania.

Simona Olimpia Dima (SO)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Fundeni Clinical Institute, 022328 Bucharest, Romania.

Ioana Raluca Florea (IR)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.

Daniela Lixandru (D)

Fundeni Clinical Institute, 022328 Bucharest, Romania.
Department of Biochemistry, 'Carol Davila' University of Medicine and Pharmacy, 050047 Bucharest, Romania.

Andreea Madalina Serban (AM)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Fundeni Clinical Institute, 022328 Bucharest, Romania.

Veronica Madalina Aspritoiu (VM)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.

Cristiana Tanase (C)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Department of Biochemistry-Proteomics,'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.

Irinel Popescu (I)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Fundeni Clinical Institute, 022328 Bucharest, Romania.

Sarah Ferber (S)

'Nicolae Cajal' Institute, 'Titu Maiorescu' University, 004051 Bucharest, Romania.
Center for Stem Cells and Regenerative Medicine, Sheba Medical Center, 5262000 Hashomer, Israel.
Orgenesis Ltd., 6997801 Aviv, Israel.
Department of Human Genetics, Aviv University, Sackler School of Medicine, 6997801 Aviv, Israel.

Classifications MeSH