Biochemical parameters and pathogenesis of SARS-CoV-2 infection in vital organs: COVID-19 outbreak in Iran.
Acute respiratory distress syndrome
angiotensin-converting enzyme 2
coronavirus
coronavirus disease 2019
severe acute respiratory syndrome coronavirus 2
Journal
New microbes and new infections
ISSN: 2052-2975
Titre abrégé: New Microbes New Infect
Pays: England
ID NLM: 101624750
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
24
07
2020
revised:
11
10
2020
accepted:
13
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
entrez:
26
10
2020
Statut:
ppublish
Résumé
Since its emergence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and led to ever-increasing mortality. SARS-CoV-2 infection perturbs the function of the body's vital organs, making patients of all ages susceptible to the disease. Nevertheless, individuals developing critical illness with poor outcomes were mostly the elderly and people with co-morbid conditions, who constituted the vast majority of coronavirus disease 2019 (COVID-19) fatalities. Complications of COVID-19 mostly involve the respiratory, renal and cardiovascular systems, and in severe cases secondary infections leading to pneumonia and acute respiratory distress syndrome, which may precede the death of the patient. Multi-organ failure in individuals with COVID-19 could be a consequence of their co-morbidities. A patient's pre-existing conditions may affect the disease prognosis, requiring immediate attention to accurately detect and evaluate them in SARS-CoV-2-infected individuals. This review addresses several issues in relation to manifestations of the body's vital organs along with potential diagnostic blood factors in SARS-CoV-2 infection. It is hoped that the review will lead to more comprehensive understanding of this complex disease.
Identifiants
pubmed: 33101694
doi: 10.1016/j.nmni.2020.100792
pii: S2052-2975(20)30144-X
pmc: PMC7568509
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100792Informations de copyright
© 2020 The Authors.
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