Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease.
Alzheimer's disease
amyloid beta
copper
isotopes
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
06
2020
revised:
30
08
2020
accepted:
02
09
2020
pubmed:
27
10
2020
medline:
27
10
2020
entrez:
26
10
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD) is neuropathologically marked by amyloid beta (Aβ) plaques and neurofibrillary tangles. Little is known about isotopic compositions of human AD brains. Here we study this in comparison with control subjects for copper and zinc. We use mass-spectrometry methods, developed to study extraterrestrial materials, to compare the copper and zinc isotopic composition of 10 AD and 10 control brains. Copper and zinc natural isotopic compositions of AD brains are statistically different compared to controls, and correlate with Braak stages. The distribution of natural copper and zinc isotopes in AD is not affected by the diet, but is a consequence of Aβ plaques and tau fibril accumulation. This is well predicted by the changes of the chemical bonding environment caused by the development of Aβ lesions and accumulation of tau proteins. Future work will involve testing whether these changes affect brain functions and are propagated to body fluids.
Identifiants
pubmed: 33102682
doi: 10.1002/dad2.12112
pii: DAD212112
pmc: PMC7571480
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12112Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
There are not conflicts of interest.
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