Association of Volume Overload With Kidney Function Outcomes Among Patients With Heart Failure With Reduced Ejection Fraction.
cardiorenal syndrome
congestion
heart failure with reduced ejection fraction
natriuretic peptides
volume overload
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
24
06
2020
accepted:
14
07
2020
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
In patients with heart failure with reduced ejection fraction (HFrEF), volume overload is associated with mortality. Few studies that have examined the relation between volume and long-term kidney function outcomes in HFrEF. Using data from the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) trial, we used multivariable Cox regression models to evaluate the association between volume overload as evaluated by B-type natriuretic peptide (BNP) and N-terminal pro B-type natriuretic peptide (NT-proBNP), and a clinical congestion score (scale of 0-12) composed of pedal edema, jugular venous distension, rales, and orthopnea with the occurrence of estimated glomerular filtration rate (eGFR) decline by >40%, and incident chronic kidney disease (CKD) stage ≥4 defined by eGFR of <30 ml/min per 1.73 m Among 3718 patients (mean eGFR 59 ± 22 ml/min per 1.73 m Volume overload, as indicated both by elevated natriuretic peptides and clinical signs and symptoms, is associated with increased risk for clinically important kidney function outcomes in HFrEF.
Identifiants
pubmed: 33102958
doi: 10.1016/j.ekir.2020.07.015
pii: S2468-0249(20)31380-2
pmc: PMC7569703
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1661-1669Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK007777
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2020 International Society of Nephrology. Published by Elsevier Inc.
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