AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer.
Cancer
Cell Biology
Stem Cells Research
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Nov 2020
20 Nov 2020
Historique:
received:
22
08
2018
revised:
03
08
2020
accepted:
02
10
2020
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of stemness traits in cancer by co-option of a regulatory function normally reserved for stem cells. AXL-expressing cells in human mammary epithelial ducts co-expressed markers associated with multipotency, and AXL inhibition abolished colony formation and self-maintenance activities while promoting terminal differentiation
Identifiants
pubmed: 33103086
doi: 10.1016/j.isci.2020.101649
pii: S2589-0042(20)30841-5
pmc: PMC7578759
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101649Subventions
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG033176
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG040081
Pays : United States
Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
J.B.L. is founder and shareholder of BerGenBio ASA. K.W.L., G.G. and J.B.L. are former or current employees of BerGenBio ASA. J.P.T. is scientific founder and CSO of Biocheetah Pte Ltd Singapore and consultant/shareholder Biosyngen Pte Lte Limited and ACTgenomics Taipei Taiwan. S.C. and R.A.B. signed Sponsored Research Agreements with BerGenBio ASA related to a separate research project. The remaining authors declare no conflict of interest.
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