Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.
Journal
STAR protocols
ISSN: 2666-1667
Titre abrégé: STAR Protoc
Pays: United States
ID NLM: 101769501
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
ppublish
Résumé
Thalamus is a critical information relay hub in the cortex; its malfunction causes multiple neurological and psychiatric disorders. However, there are no model systems to study the development and function of human thalamus. Here, we present a protocol to generate regionally specified human brain organoids that recapitulate the development of the thalamus using human pluripotent stem cells (hPSCs). Thalamic organoids can be used to study human thalamus development, to model related diseases, and to discover potential therapeutics. For complete information on human thalamic organoids and their application, please refer to the paper by Xiang et al. (2019).
Identifiants
pubmed: 33103124
doi: 10.1016/j.xpro.2019.100001
pmc: PMC7580078
mid: NIHMS1611660
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA025080
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203011
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM111667
Pays : United States
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS The authors declare no competing interests.
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