Putting the spotlight on donation-related risks and donor safety - are we succeeding in protecting donors?
blood safety
donor health
donors
hemovigilance
Journal
Vox sanguinis
ISSN: 1423-0410
Titre abrégé: Vox Sang
Pays: England
ID NLM: 0413606
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
revised:
14
09
2020
received:
29
05
2020
accepted:
15
09
2020
pubmed:
27
10
2020
medline:
21
5
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
The European consortium project TRANSPOSE (TRANSfusion and transplantation: PrOtection and SElection of donors) aimed to assess and evaluate the risks to donors of Substances of Human Origin (SoHO), and to identify gaps between current donor vigilance systems and perceived risks. National and local data from participating organizations on serious and non-serious adverse reactions in donors were collected from 2014 to 2017. Following this, a survey was performed among participants to identify risks not included in the data sets. Finally, participants rated the risks according to severity, level of evidence and prevalence. Significant discrepancies between anticipated donor risks and the collected data were found. Furthermore, many participants reported that national data on adverse reactions in donors of stem cells, gametes, embryos and tissues were not routinely collected and/or available. These findings indicate that there is a need to further develop and standardize donor vigilance in Europe and to include long-term risks to donors, which are currently underreported, ensuring donor health and securing the future supply of SoHO.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
The European consortium project TRANSPOSE (TRANSfusion and transplantation: PrOtection and SElection of donors) aimed to assess and evaluate the risks to donors of Substances of Human Origin (SoHO), and to identify gaps between current donor vigilance systems and perceived risks.
MATERIALS AND METHODS
METHODS
National and local data from participating organizations on serious and non-serious adverse reactions in donors were collected from 2014 to 2017. Following this, a survey was performed among participants to identify risks not included in the data sets. Finally, participants rated the risks according to severity, level of evidence and prevalence.
RESULTS
RESULTS
Significant discrepancies between anticipated donor risks and the collected data were found. Furthermore, many participants reported that national data on adverse reactions in donors of stem cells, gametes, embryos and tissues were not routinely collected and/or available.
CONCLUSIONS
CONCLUSIONS
These findings indicate that there is a need to further develop and standardize donor vigilance in Europe and to include long-term risks to donors, which are currently underreported, ensuring donor health and securing the future supply of SoHO.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-323Subventions
Organisme : the European Union's Health Programme (2014-2020).
ID : 738145 / TRANSPOSE'
Informations de copyright
© 2020 International Society of Blood Transfusion.
Références
Evatt B: Infectious disease in the blood supply and the public health response. Semin Hematol 2006; 43:S4-9
Solves P, Mirabet V, Alvarez M: Hepatitis B transmission by cell and tissue allografts: How safe is safe enough? World J Gastroenterol 2014; 20:7434-41
Leparc GF: Safety of the blood supply. Cancer Control 2015; 22:7-15
Seo DH, Whang DH, Song EY, et al.: Occult hepatitis B virus infection and blood transfusion. World J Hepatol 2015; 7:600-6
Garraud O, Filho LA, Laperche S, et al.: The infectious risks in blood transfusion as of today - A no black and white situation. Press Med 2016; 45(7-8 Pt 2):e303-11
Graw JA, Eymann K, Kork F, et al.: Risk perception of blood transfusions - A comparison of patients and allied healthcare professionals. BMC Health Serv Res 2018; 18:122
De Kort W, Mayr W, Jungbauer C, et al.: Blood donor selection in European Union directives: Room for improvement. Blood Transfus 2016; 14:101-8
Goldman M, Uzicanin S, Scalia V, et al.: Iron deficiency in Canadian blood donors. Transfusion 2014; 54:775-9
Rigas AS, Pedersen OB, Magnussen K, et al.: Iron deficiency among blood donors: experience from the Danish Blood Donor Study and from the Copenhagen ferritin monitoring scheme. Transfus Med 2019; 29:23-7
Bialkowski W, Bruhn R, Edgren G, et al.: Citrate anticoagulation: Are blood donors donating bone? J Clin Apher 2016; 31:459-63
Grau K, Vasan SK, Rostgaard K, et al.: No association between frequent apheresis donation and risk of fractures: a retrospective cohort analysis from Sweden. Transfusion 2017; 57:390-6
Burgin M, Hopkins G, Moore B, et al.: Serum IgG and IgM levels in new and regular long-term plasmapheresis donors. Med Lab Sci 1992; 49:265-70
Lewis SL, Kutvirt SG, Bonner PN, et al.: Plasma proteins and lymphocyte phenotypes in long-term plasma donors. Transfusion 1994; 34:587-85
Jansson U: Collection of plasma considering the calculated blood volume of the individual donor. Effects for donors, plasma collection, collection routines and economy. Report to the National Board of health and Welfare, Sweden. 2013.
Tran-Mi B, Storch H, Seidel K, et al.: The impact of different intensities of regular donor plasmapheresis on humoral and cellular immunity, red cell and iron metabolism, and cardiovascular risk markers. Vox Sang 2004; 86:189-97
Hellstern P, Bach J, Haubelt H, et al.: The impact of the intensity of serial automated plasmapheresis and the speed of deep-freezing on the quality of plasma. Transfusion 2001; 41:1601-5
Anthias C, Ethell ME, Potter MN, et al.: The impact of improved JACIE standards on the care of related BM and PBSC donors. Bone Marrow Transplant 2015; 50:244-7
Alberta HB, Berry RM, Levine AD: Risk disclosure and the recruitment of oocyte donors: are advertisers telling the full story? J Law Med Ethics 2014; 42:232-43
Kramer W, Schneider J, Schultz N: US oocyte donors: a retrospective study of medical and psychosocial issues. Hum Reprod 2009; 24:3144-9
Williams RA, Machin LL: Rethinking gamete donor care: A satisfaction survey of egg and sperm donors in the UK. PLoS One 2018; 13:e0199971
Bracewell-Milnes T, Saso S, Abdalla H, et al.: A systematic review investigating psychosocial aspects of egg sharing in the United Kingdom and their potential effects on egg donation numbers. Hum Fertil (Camb) 2018; 21:163-73
Visser M, Mochtar MH, de Melker AA, et al.: Psychosocial counselling of identifiable sperm donors. Hum Reprod 2016; 31:1066-74
Schneider J: Fatal colon cancer in a young egg donor: a physician mother’s call for follow-up and research on the long-term risks of ovarian stimulation. Fertil Steril 2008; 90:2016.e1-5
Schneider J, Lahl J, Kramer W: Long-term breast cancer risk following ovarian stimulation in young egg donors: a call for follow-up, research and informed consent. Reprod Biomed Online 2017; 34:480-5
Fauser BC, Garcia Velasco J: Breast cancer risk after oocyte donation: should we really be concerned? Reprod Biomed Online 2017; 34:439-40
Leal de Moraes E, de Barros e Silva LB, Pilan L, et al.: My loved one was not an organ donor: ethical dilemmas for family members of deceased potential donors when making the decision on donation. Transplant Proc 2019; 51:1540-1544.
Goldman M, Land K, Robillard P, et al.: Development of standard definitions for surveillance of complications related to blood donation. Vox Sang 2016; 110:185-8
Wiersum-Osselton JC, Marijt-van der Kreek T, de Kort WLAM: Donor vigilance: What are we doing about it? Biologicals 2012; 40:176-9
Land KJ, Townsend M, Goldman M, et al.: International validation of harmonized definitions for complications of blood donations. Transfusion 2018; 58:2589-95
Di Angelantonio E, Thompson SG, Kaptoge S, et al.: Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors. Lancet (London, England) 2017; 390:2360-71
Cable RG, Glynn SA, Kiss JE, et al.: Iron deficiency in blood donors: the REDS-II Donor Iron Status Evaluation (RISE) study. Transfusion 2012; 52:702-11
Halter JP, van Walraven SM, Worel N, et al.: Allogeneic hematopoietic stem cell donation-standardized assessment of donor outcome data: a consensus statement from the Worldwide Network for Blood and Marrow Transplantation (WBMT). Bone Marrow Transplant 2013; 48:220-5
Anthias C, van Walraven SM, Sorensen BS, et al.: Related hematopoietic cell donor care: is there a role for unrelated donor registries? Bone Marrow Transplant 2015; 50:637-41