FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update.

Animals Animals, Genetically Modified Computational Biology / methods Databases, Genetic Drosophila Proteins / genetics Drosophila melanogaster / genetics Gene Expression Profiling / methods Genome, Insect / genetics Genomics / methods Information Storage and Retrieval Internet RNA Interference

Journal

Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011

Informations de publication

Date de publication:
08 01 2021
Historique:
accepted: 06 10 2020
revised: 01 10 2020
received: 03 09 2020
pubmed: 27 10 2020
medline: 2 2 2021
entrez: 26 10 2020
Statut: ppublish

Résumé

The FlyRNAi database at the Drosophila RNAi Screening Center and Transgenic RNAi Project (DRSC/TRiP) provides a suite of online resources that facilitate functional genomics studies with a special emphasis on Drosophila melanogaster. Currently, the database provides: gene-centric resources that facilitate ortholog mapping and mining of information about orthologs in common genetic model species; reagent-centric resources that help researchers identify RNAi and CRISPR sgRNA reagents or designs; and data-centric resources that facilitate visualization and mining of transcriptomics data, protein modification data, protein interactions, and more. Here, we discuss updated and new features that help biological and biomedical researchers efficiently identify, visualize, analyze, and integrate information and data for Drosophila and other species. Together, these resources facilitate multiple steps in functional genomics workflows, from building gene and reagent lists to management, analysis, and integration of data.

Identifiants

DOI: 10.1093/nar/gkaa936 PMID: 33104800 PMC: PMC7778949
pubmed: 33104800
pii: 5940514
doi: 10.1093/nar/gkaa936
pmc: PMC7778949
doi:

Substances chimiques

Drosophila Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

D908-D915

Subventions

Organisme : NIGMS NIH HHS
ID : P41 GM132087
Pays : United States
Organisme : NIH HHS
ID : R24 OD021997
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006516
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM067761
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM084947
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

Références

Nucleic Acids Res. 2019 Jan 8;47(D1):D759-D765
pubmed: 30364959
Bioinformatics. 2017 Apr 15;33(8):1154-1159
pubmed: 28096085
Nucleic Acids Res. 2019 Jan 8;47(D1):D801-D806
pubmed: 30407599
Nucleic Acids Res. 2012 Jan;40(Database issue):D715-9
pubmed: 22067456
Cold Spring Harb Protoc. 2016 Sep 01;2016(9):
pubmed: 27587779
Database (Oxford). 2020 Jan 1;2020:
pubmed: 32353878
Genetics. 2020 Apr;214(4):755-767
pubmed: 32071193
Curr Protoc Mol Biol. 2020 Mar;130(1):e112
pubmed: 31869524
Dev Cell. 2018 Nov 5;47(3):294-305.e7
pubmed: 30293839
Cell. 2012 Sep 28;151(1):123-37
pubmed: 23021220
Nat Biotechnol. 2015 Jun;33(6):661-7
pubmed: 25961408
Nat Methods. 2014 Jan;11(1):94-9
pubmed: 24240319
Proc Natl Acad Sci U S A. 2016 May 3;113(18):4976-81
pubmed: 27091990
G3 (Bethesda). 2019 Jan 9;9(1):1-11
pubmed: 30397019
Nucleic Acids Res. 2017 Jan 4;45(D1):D672-D678
pubmed: 27924039
J Genomics. 2015 Jul 01;3:75-81
pubmed: 26157507
Elife. 2019 Nov 01;8:
pubmed: 31674908
Am J Hum Genet. 2017 Jun 1;100(6):843-853
pubmed: 28502612
BMC Bioinformatics. 2017 Feb 10;18(1):98
pubmed: 28187709
G3 (Bethesda). 2020 Feb 6;10(2):489-494
pubmed: 31822517
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12093-8
pubmed: 26362788
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1514-1523
pubmed: 31915294
Cell Rep. 2016 Sep 13;16(11):3062-3074
pubmed: 27626673
Elife. 2020 May 12;9:
pubmed: 32396065
Curr Protoc Mol Biol. 2019 Dec;129(1):e111
pubmed: 31763777
Elife. 2018 Jul 27;7:
pubmed: 30051818
Nucleic Acids Res. 2020 Jan 8;48(D1):D762-D767
pubmed: 31642470
BMC Bioinformatics. 2011 Aug 31;12:357
pubmed: 21880147
G3 (Bethesda). 2017 Aug 7;7(8):2855-2858
pubmed: 28663344
Nat Commun. 2019 Oct 4;10(1):4541
pubmed: 31586052
Genetics. 2013 Sep;195(1):37-45
pubmed: 23792952
Elife. 2018 Mar 22;7:
pubmed: 29565247
Nucleic Acids Res. 2019 Jan 8;47(D1):D529-D541
pubmed: 30476227
Nucleic Acids Res. 2012 Jan;40(Database issue):D841-6
pubmed: 22121220
Genome Biol. 2019 Nov 14;20(1):238
pubmed: 31727128
Bioinformatics. 2012 Dec 1;28(23):3163-5
pubmed: 23023984
Nucleic Acids Res. 2020 Jan 8;48(D1):D650-D658
pubmed: 31552413
Genetics. 2015 Nov;201(3):843-52
pubmed: 26320097
G3 (Bethesda). 2013 Sep 04;3(9):1607-16
pubmed: 23893746
Nucleic Acids Res. 2019 Jan 8;47(D1):D411-D418
pubmed: 30380106
Sci Signal. 2015 Sep 08;8(393):rs9
pubmed: 26350902
Nucleic Acids Res. 2019 Jan 8;47(D1):D867-D873
pubmed: 30407545
Genetics. 2019 Dec;213(4):1189-1196
pubmed: 31796553
Nucleic Acids Res. 2018 Jan 4;46(D1):D567-D574
pubmed: 29155944
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W468-72
pubmed: 24753429
Sci Signal. 2013 Feb 26;6(264):rs5
pubmed: 23443684
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D489-94
pubmed: 16381918
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19012-7
pubmed: 24191015

Auteurs

Yanhui Hu (Y)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Aram Comjean (A)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Jonathan Rodiger (J)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Yifang Liu (Y)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Yue Gao (Y)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Verena Chung (V)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Jonathan Zirin (J)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Norbert Perrimon (N)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Stephanie E Mohr (SE)

Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Drosophila RNAi Screening Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Bases de données génétiques › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome d'insecte › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Systèmes informatiques › Réseaux de communication entre ordinateurs › Internet › FlyRNAi.org-the database of the Drosophila...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › FlyRNAi.org-the database of the Drosophila...