Airborne transmission of SARS-CoV-2 via aerosols.
Covid-19
SARS-CoV-2
aerosols
coronavirus
infection control
review
transmission
Journal
Reviews in medical virology
ISSN: 1099-1654
Titre abrégé: Rev Med Virol
Pays: England
ID NLM: 9112448
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
08
10
2020
received:
01
09
2020
accepted:
10
10
2020
pubmed:
27
10
2020
medline:
1
6
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
A key consideration in the Covid-19 pandemic is the dominant modes of transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The objective of this review was to synthesise the evidence for the potential airborne transmission of SARS-CoV-2 via aerosols. Systematic literature searches were conducted in PubMed, Embase, Europe PMC and National Health Service UK evidence up to 27 July 2020. A protocol was published and Cochrane guidance for rapid review methodology was adhered to throughout. Twenty-eight studies were identified. Seven out of eight epidemiological studies suggest aerosol transmission may occur, with enclosed environments and poor ventilation noted as possible contextual factors. Ten of the 16 air sampling studies detected SARS-CoV-2 ribonucleic acid; however, only three of these studies attempted to culture the virus with one being successful in a limited number of samples. Two of four virological studies using artificially generated aerosols indicated that SARS-CoV-2 is viable in aerosols. The results of this review indicate there is inconclusive evidence regarding the viability and infectivity of SARS-CoV-2 in aerosols. Epidemiological studies suggest possible transmission, with contextual factors noted. Viral particles have been detected in air sampling studies with some evidence of clinical infectivity, and virological studies indicate these particles may represent live virus, adding further plausibility. However, there is uncertainty as to the nature and impact of aerosol transmission of SARS-CoV-2, and its relative contribution to the Covid-19 pandemic compared with other modes of transmission.
Identifiants
pubmed: 33105071
doi: 10.1002/rmv.2184
pmc: PMC7645866
doi:
Substances chimiques
Aerosols
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2184Subventions
Organisme : Health Research Board
ID : HRB-CICER-2016-1871
Pays : Ireland
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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