Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19.


Journal

Gerontology
ISSN: 1423-0003
Titre abrégé: Gerontology
Pays: Switzerland
ID NLM: 7601655

Informations de publication

Date de publication:
2020
Historique:
received: 10 07 2020
accepted: 10 10 2020
pubmed: 27 10 2020
medline: 29 12 2020
entrez: 26 10 2020
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a recent outbreak of coronavirus disease (COVID-19). In Cuba, the first case of COVID-19 was reported on March 11, 2020. Elderly individuals with multiple comorbidities are particularly susceptible to adverse clinical outcomes in the course of SARS-CoV-2 infection. During the outbreak, a local transmission event took place in a nursing home in Villa Clara province, Cuba, in which 19 elderly residents tested positive for SARS-CoV-2. Based on the increased susceptibility to cytokine release syndrome, inducing respiratory and systemic complications in this population, 19 patients were included in an expanded access clinical trial to receive itolizumab, an anti-CD6 monoclonal antibody. All patients had underlying medical conditions. The product was well tolerated. After the first dose, the course of the disease was favorable, and 18 of the 19 patients (94.7%) were discharged clinically recovered with negative real-time reverse transcription polymerase chain reaction test results at 13 days. After one dose of itolizumab, circulating IL-6 decreased within the first 24-48 h in patients with high baseline values, whereas in patients with low levels, this concentration remained over low values. To preliminarily assess the effect of itolizumab, a control group was selected among the Cuban COVID-19 patients that did not receive immunomodulatory therapy. The control subjects were well matched regarding age, comorbidities, and severity of the disease. The percentage of itolizumab-treated, moderately ill patients who needed to be admitted to the intensive care unit was only one-third of that of the control group not treated with itolizumab. Additionally, treatment with itolizumab reduced the risk of death 10 times as compared with the control group. This study corroborates that the timely use of itolizumab in combination with other antivirals reduces COVID-19 disease worsening and mortality. The humanized antibody itolizumab emerges as a therapeutic alternative for patients with COVID-19. Our results suggest the possible use of itolizumab in patients with cytokine release syndrome from other pathologies.

Sections du résumé

BACKGROUND
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a recent outbreak of coronavirus disease (COVID-19). In Cuba, the first case of COVID-19 was reported on March 11, 2020. Elderly individuals with multiple comorbidities are particularly susceptible to adverse clinical outcomes in the course of SARS-CoV-2 infection. During the outbreak, a local transmission event took place in a nursing home in Villa Clara province, Cuba, in which 19 elderly residents tested positive for SARS-CoV-2.
METHODS
Based on the increased susceptibility to cytokine release syndrome, inducing respiratory and systemic complications in this population, 19 patients were included in an expanded access clinical trial to receive itolizumab, an anti-CD6 monoclonal antibody.
RESULTS
All patients had underlying medical conditions. The product was well tolerated. After the first dose, the course of the disease was favorable, and 18 of the 19 patients (94.7%) were discharged clinically recovered with negative real-time reverse transcription polymerase chain reaction test results at 13 days. After one dose of itolizumab, circulating IL-6 decreased within the first 24-48 h in patients with high baseline values, whereas in patients with low levels, this concentration remained over low values. To preliminarily assess the effect of itolizumab, a control group was selected among the Cuban COVID-19 patients that did not receive immunomodulatory therapy. The control subjects were well matched regarding age, comorbidities, and severity of the disease. The percentage of itolizumab-treated, moderately ill patients who needed to be admitted to the intensive care unit was only one-third of that of the control group not treated with itolizumab. Additionally, treatment with itolizumab reduced the risk of death 10 times as compared with the control group.
CONCLUSION
This study corroborates that the timely use of itolizumab in combination with other antivirals reduces COVID-19 disease worsening and mortality. The humanized antibody itolizumab emerges as a therapeutic alternative for patients with COVID-19. Our results suggest the possible use of itolizumab in patients with cytokine release syndrome from other pathologies.

Identifiants

pubmed: 33105142
pii: 000512210
doi: 10.1159/000512210
pmc: PMC7649683
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antibodies, Monoclonal, Humanized 0
itolizumab XQQ2RHV14N

Types de publication

Clinical Trial Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

553-561

Informations de copyright

© 2020 S. Karger AG, Basel.

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Auteurs

Yayquier Díaz (Y)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Mayra Ramos-Suzarte (M)

Center of Molecular Immunology, Playa, Havana, Cuba, mayra@cim.sld.cu.

Yordanis Martín (Y)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Néstor Antonio Calderón (NA)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

William Santiago (W)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Orlando Viñet (O)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Yulieski La O (Y)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Jorge Pérez Augusto Oyarzábal (JPA)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Yoan Pérez (Y)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

Geidy Lorenzo (G)

Center of Molecular Immunology, Playa, Havana, Cuba.

Meylan Cepeda (M)

Center of Molecular Immunology, Playa, Havana, Cuba.

Danay Saavedra (D)

Center of Molecular Immunology, Playa, Havana, Cuba.

Zaima Mazorra (Z)

Center of Molecular Immunology, Playa, Havana, Cuba.

Daymys Estevez (D)

Center of Molecular Immunology, Playa, Havana, Cuba.

Patricia Lorenzo-Luaces (P)

Center of Molecular Immunology, Playa, Havana, Cuba.

Carmen Valenzuela (C)

Center of Molecular Immunology, Playa, Havana, Cuba.

Armando Caballero (A)

Arnaldo Milian Castro University Hospital, Santa Clara, Cuba.

Kalet Leon (K)

Center of Molecular Immunology, Playa, Havana, Cuba.

Tania Crombet (T)

Center of Molecular Immunology, Playa, Havana, Cuba.

Carlos Jorge Hidalgo (CJ)

Manuel Fajardo University Hospital, Santa Clara, Cuba.

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Classifications MeSH