Achalasia Is Associated With Atopy in Patients Younger Than 40 Years of Age.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Autoimmune Diseases
/ epidemiology
Cohort Studies
Esophageal Achalasia
/ epidemiology
Female
Humans
Hypersensitivity
/ epidemiology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Neurodegenerative Diseases
/ epidemiology
United Kingdom
/ epidemiology
Young Adult
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
25
06
2020
accepted:
21
09
2020
pubmed:
27
10
2020
medline:
2
3
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions. This is a UK cohort study of 2,593 subjects with achalasia matched to 10,402 controls. At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95% confidence interval 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) in those aged younger than 40 years. Our findings support an autoimmune etiology in achalasia but also suggest a possible atopic etiology in younger subjects.
Identifiants
pubmed: 33105192
pii: 00000434-202102000-00035
doi: 10.14309/ajg.0000000000001006
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
416-419Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 by The American College of Gastroenterology.
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