Myosin Heavy Chain Composition, Creatine Analogues, and the Relationship of Muscle Creatine Content and Fast-Twitch Proportion to Wilks Coefficient in Powerlifters.
Adolescent
Adult
Athletic Performance
/ physiology
Creatine
/ blood
Female
Humans
Male
Muscle Fibers, Fast-Twitch
/ physiology
Muscle Fibers, Skeletal
/ physiology
Myosin Heavy Chains
/ biosynthesis
Nerve Tissue Proteins
/ blood
Plasma Membrane Neurotransmitter Transport Proteins
/ blood
Protein Isoforms
Quadriceps Muscle
/ physiology
Sex Factors
Weight Lifting
/ physiology
Young Adult
Journal
Journal of strength and conditioning research
ISSN: 1533-4287
Titre abrégé: J Strength Cond Res
Pays: United States
ID NLM: 9415084
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
7
4
2021
Statut:
ppublish
Résumé
Machek, SB, Hwang, PS, Cardaci, TD, Wilburn, DT, Bagley, JR, Blake, DT, Galpin, AJ, and Willoughby, DS. Myosin heavy chain composition, creatine analogues, and the relationship of muscle creatine content and fast-twitch proportion to Wilks coefficient in powerlifters. J Strength Cond Res 34(11): 3022-3030, 2020-Little data exist on powerlifting-specific skeletal muscle adaptations, and none elucidate sex differences in powerlifters. Powerlifters tend to display higher fast-twitch fiber content and phosphagen system dependence. Nevertheless, it is unknown whether fast-twitch fiber or muscle creatine content are predictive of competitive powerlifting performance (via Wilks coefficient). Twelve actively competing powerlifters (PL; n = 6M/6F; age = 21.3 ± 1.0; 3.0 ± 1.8 year competing; 7.3 ± 6.6 meets attended) and 10 sedentary controls (CON; n = 5M/5F; age = 19.4 ± 2.0 year) underwent vastus lateralis muscle biopsies and venipuncture to compare the myosin heavy chain (MHC) fiber type and creatine analogue profiles between groups of both sexes, and determine whether MHC IIa and muscle total creatine (MTC) composition predict powerlifting performance. Samples were analyzed for specific MHC isoform (I, IIa, and IIx) content via mixed homogenate SDS-PAGE, and creatine analogues (MTC, muscle creatine transporter [SLC6A8], serum total creatine [STC], and serum creatinine [CRT]). Furthermore, MHC IIa and MTC content were compared with Wilks coefficient using Pearson correlation coefficients. Male PL MHC content was 50 ± 6% I, 45 ± 6% IIa, and 5 ± 11% IIx, versus 46 ± 6% I, 53 ± 6 IIa, and 0% IIx in female PL. Conversely, male CON MHC content was 33 ± 5% I, 38 ± 7% IIa, and 30 ± 8% IIx, vs. 35 ± 9% I, 44 ± 8% IIa, and 21 ± 17% IIx in female CON. Muscle total creatine, SLC6A8, STC, and CRT did not significantly differ between groups nor sexes. Finally, neither MHC IIa content (r = -0.288; p = 0.364) nor MTC (r = 0.488; p = 0.108) significantly predicted Wilks coefficient, suggesting these characteristics alone do not determine powerlifting skill variation.
Identifiants
pubmed: 33105350
doi: 10.1519/JSC.0000000000003804
pii: 00124278-202011000-00002
doi:
Substances chimiques
Nerve Tissue Proteins
0
Plasma Membrane Neurotransmitter Transport Proteins
0
Protein Isoforms
0
SLC6A8 protein, human
0
Myosin Heavy Chains
EC 3.6.4.1
Creatine
MU72812GK0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3022-3030Références
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