Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
20
02
2020
accepted:
20
09
2020
pubmed:
28
10
2020
medline:
14
4
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Delivery of vesicles to their desired destinations plays a central role in maintaining proper cell functionality. In certain scenarios, depending on loaded cargos, the vesicles have spatially distinct destinations. For example, in T cells, some cytokines (e.g., IL-2) are polarized to the T cell-target cell interface, whereas the other cytokines are delivered multidirectionally (e.g., TNF-α). In this study, we show that in primary human CD4
Identifiants
pubmed: 33106338
pii: jimmunol.2000195
doi: 10.4049/jimmunol.2000195
doi:
Substances chimiques
Cytokines
0
Dyneins
EC 3.6.4.2
Kinesins
EC 3.6.4.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2988-3000Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.