Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities.
epidermal devices
galvanic skin response
healthcare
soft materials
sweat cortisol
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
pubmed:
28
10
2020
medline:
8
1
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.
Identifiants
pubmed: 33106394
pii: 2012700117
doi: 10.1073/pnas.2012700117
pmc: PMC7668081
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
27906-27915Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: J.A.R., J.T.R., Y.S., and S.K. are inventors on a Patent Cooperation Treaty (PCT) patent application filed by the board of trustees of Northwestern University (PCT/US2018/035661), and J.A.R., J.T.R., S.K., Y.S., and A.H.-F. are inventors on a PCT patent application filed by the board of trustees of Northwestern University (PCT/US2018/035738). R.G., A.J.A., J.B.M., S.P.L., and J.A.R. are cofounders of Epicore Biosystems Inc., which pursues commercialization of epifluidic devices.
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