Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia.
ARNTL Transcription Factors
/ genetics
Anesthetics, Inhalation
/ administration & dosage
Animals
CLOCK Proteins
/ genetics
Circadian Rhythm
/ drug effects
Cryptochromes
/ genetics
Desflurane
/ administration & dosage
Gene Expression Regulation
/ drug effects
Male
Mice
Period Circadian Proteins
/ genetics
Suprachiasmatic Nucleus
/ chemistry
Time
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 10 2020
26 10 2020
Historique:
received:
01
05
2020
accepted:
12
10
2020
entrez:
27
10
2020
pubmed:
28
10
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
Identifiants
pubmed: 33106509
doi: 10.1038/s41598-020-75434-6
pii: 10.1038/s41598-020-75434-6
pmc: PMC7588451
doi:
Substances chimiques
ARNTL Transcription Factors
0
Anesthetics, Inhalation
0
Bmal1 protein, mouse
0
Cry1 protein, mouse
0
Cryptochromes
0
Per2 protein, mouse
0
Period Circadian Proteins
0
Desflurane
CRS35BZ94Q
CLOCK Proteins
EC 2.3.1.48
Clock protein, mouse
EC 2.3.1.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18273Commentaires et corrections
Type : ErratumIn
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