B cells and the microbiota: a missing connection in food allergy.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
13
07
2020
accepted:
02
10
2020
revised:
15
09
2020
pubmed:
28
10
2020
medline:
13
10
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Food allergies are a major public health concern due to their widespread and rising prevalence. The increase in food allergy is partially due to Western lifestyle habits which deplete protective commensal microbiota. These microbial perturbations can result in adverse host-microbe interactions, altering the phenotype of various immune cells and instigating allergic sensitization. Although B cells are critical to allergic pathology, microbial influences on B cells have been somewhat overlooked. Here, we focus on direct and indirect interactions between bacteria and B cells and how such interactions regulate B-cell phenotype, namely antibody production (IgA, IgE, IgG1, and IgG4) and regulatory B-cell (Breg) function. Understanding how microbes modulate B-cell activity in the context of food allergies is critical to both tracing the development of disease and assessing future treatment options.
Identifiants
pubmed: 33106585
doi: 10.1038/s41385-020-00350-x
pii: S1933-0219(22)00103-9
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-13Subventions
Organisme : NIGMS NIH HHS
ID : R25 GM109439
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106302
Pays : United States
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