GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.
G protein subunit alpha O1 (GNAO1)
cytoskeleton
developmental and epileptic encephalopathy
non-erythrocytic 1 (SPTAN1)
organoid
spectrin alpha
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
05
2020
revised:
03
09
2020
accepted:
13
10
2020
pubmed:
28
10
2020
medline:
23
4
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Developmental and epileptic encephalopathy (DEE) represents a group of neurodevelopmental disorders characterized by infantile-onset intractable seizures and unfavorable prognosis of psychomotor development. To date, hundreds of genes have been linked to the onset of DEE. GNAO1 is a DEE-associated gene encoding the alpha-O1 subunit of guanine nucleotide-binding protein (Gα
Identifiants
pubmed: 33107105
doi: 10.1096/fj.202001113R
doi:
Substances chimiques
GNAO1 protein, human
0
GNAO1 protein, mouse
EC 3.6.5.1
GTP-Binding Protein alpha Subunits, Gi-Go
EC 3.6.5.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16601-16621Informations de copyright
© 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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